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Impact of MUC1 Expression on the Progression of Intraductal Papillary Mucinous Neoplasm With Worrisome Features During Follow-up
- Source :
- Pancreas. 46:1127-1132
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Objectives The aim of this study was to investigate whether MUC1 expression is associated with progression of intraductal papillary mucinous neoplasms with worrisome features during follow-up. Methods Fifteen patients positive for MUC1 and negative for MUC2 (MUC1 group) and 16 patients negative for MUC1 and MUC2 (control group) were followed up and examined for changes in diameters of the main and ectatic branches of pancreatic ducts, enlargement of mural nodules, and appearance of a solid mass, by imaging studies. All of them presented worrisome features, and none had "high-risk stigmata." Results The sizes of the main and ectatic branches of pancreatic ducts increased in 8 (53.3%) and 8 (53.3%) patients, respectively, of the MUC1 group and in 1 (6.3%) and 1 (6.3%) patients, respectively, of the control group (P = 0.0059 and 0.0059, respectively). A solid mass developed in 6 patients (33.3%) of the MUC1 group but in none of the control group patients (P = 0.0373). Conclusions Positive MUC1 expression in cell block cytology specimens may be associated with progressive dilation of the main and ectatic branches of pancreatic ducts and appearance of a solid mass in patients with intraductal papillary mucinous neoplasm with worrisome features during follow-up.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
digestive system
03 medical and health sciences
0302 clinical medicine
Endocrinology
Ectasia
Cytology
Internal Medicine
medicine
Carcinoma
Humans
In patient
skin and connective tissue diseases
MUC1
Aged
Aged, 80 and over
Hepatology
Intraductal papillary mucinous neoplasm
business.industry
Mucin-1
Pancreatic Ducts
Solid mass
Middle Aged
medicine.disease
Adenocarcinoma, Mucinous
Carcinoma, Papillary
digestive system diseases
Pancreatic Neoplasms
030220 oncology & carcinogenesis
Disease Progression
Adenocarcinoma
Female
030211 gastroenterology & hepatology
Radiology
business
Carcinoma, Pancreatic Ductal
Follow-Up Studies
Subjects
Details
- ISSN :
- 15364828 and 08853177
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....d6652f6a01af1468cefc66dfb691838f