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Inflammasome Targeted Therapy in Pregnancy: New Insights From an Analysis of Real-World Data From the FAERS Database and a Systematic Review
- Source :
- Frontiers in Pharmacology, Frontiers in Pharmacology, Vol 11 (2021)
- Publication Year :
- 2020
-
Abstract
- The published experience with biologics in childbearing age with autoimmune and inflammatory diseases mainly deals with the use of TNFα inhibitors (TNFα-i). Limited data are available for biologics targeting other cytokines or immunocompetent cells, especially for the inflammasome targeted therapy including IL-1 inhibitors and colchicine. We conducted a nested case-control study by using the US Food and Drug Administration Adverse Event Reporting System database aimed at quantifying the association between the use of IL-1 inhibitors/colchicine in pregnant women and the occurrence of maternal/fetal adverse effects. The reporting odds ratio was used as a measure of disproportional reporting. From the total cohort (40,033 pregnant women), we retrieved 7,620 reports related to neonatal AEs, 2,889 to fetal disorders, 8,364 to abortion, 8,787 to congenital disorders, and 7,937 to labor/delivery complications. Inflammasome-targeted drugs did not present any disproportionate reporting for all these clusters of AEs. TNFα-i confirmed their safety during pregnancy with aROR < 1 for all clusters of AEs except for labor complications. Finally, we performed a systematic review of the current literature. Data from the eligible studies (12 observational studies and 6 case reports; yielding a total of 2,075 patients) were reassuring. We found no major safety issues on malformations risk of inflammasome targeted therapies in pregnancy. However, due to limited data, the routine use of these agents should be considered in pregnancy only if risk benefit assessment justifies the potential risk to the fetus.
- Subjects :
- medicine.medical_treatment
030204 cardiovascular system & hematology
Abortion
computer.software_genre
colchicine
Targeted therapy
03 medical and health sciences
Adverse Event Reporting System
0302 clinical medicine
Pharmacovigilance
pharmacovgilance
medicine
Pharmacology (medical)
Adverse effect
IL-inhibitors
030203 arthritis & rheumatology
Pharmacology
Pregnancy
Database
business.industry
lcsh:RM1-950
Odds ratio
medicine.disease
lcsh:Therapeutics. Pharmacology
pharmacovigilance
Cohort
inflammasome targeted therapy
Systematic Review
pregnancy
business
computer
Subjects
Details
- ISSN :
- 16639812
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in pharmacology
- Accession number :
- edsair.doi.dedup.....d6633117789d2e945f5f84a08ca8f25f