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Expression of polymeric immunoglobulin receptor and its biological function in endometrial adenocarcinoma
- Source :
- Journal of Cancer Research and Therapeutics, Vol 15, Iss 2, Pp 420-425 (2019)
- Publication Year :
- 2019
-
Abstract
- Aim: To investigate the expression of polymeric immunoglobulin receptor (pIgR) in endometrial adenocarcinoma and the relationship between pIgR and the clinicopathological features of endometrial adenocarcinoma. To investigate the role of pIgR in the biological behavior of endometrial adenocarcinoma cell lines. Methods: First, the paraffin-embedded endometrial adenocarcinoma samples and clinicopathological data from the Chao-Yang Hospital were collected. Next, immunohistochemistry was conducted to test the expression of pIgR in endometrial adenocarcinoma; the correlations between pIgR and clinicopathological features were detected. Then, the expression of pIgR in the Ishikawa cells was interfered with short-interfering RNA (siRNA). Finally, the migration and proliferation abilities of Ishikawa cells were detected by transwell and CCK8 assays before and after interference. Results: pIgR had a high expression level and higher H-score in endometrial adenocarcinoma (P = 0.013) than in noncancerous tissues. There was no correlation between pIgR and the histopathological features of endometrial adenocarcinoma (P ≥ 0.418). The migration ability of Ishikawa cells was increased after interference with pIgR (P = 0.023). The proliferation of Ishikawa cells was not different between the untreated and siRNA215-treated groups (P = 0.967). Conclusion: PIgR may be a predictive biomarker of endometrial adenocarcinoma and a potential target protein for immunotherapy of endometrial adenocarcinoma.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
proliferation
Endometrial adenocarcinoma
Biology
Adenocarcinoma
migration
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
medicine
Humans
Radiology, Nuclear Medicine and imaging
RNA, Small Interfering
Predictive biomarker
Cell Proliferation
Receptors, Polymeric Immunoglobulin
RNA
polymeric immunoglobulin receptor
General Medicine
Immunotherapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunohistochemistry
Endometrial Neoplasms
Gene Expression Regulation, Neoplastic
030104 developmental biology
Oncology
Cell culture
030220 oncology & carcinogenesis
Cancer research
Clinicopathological features
Female
RNA Interference
Polymeric immunoglobulin receptor
Biomarkers
Subjects
Details
- ISSN :
- 19984138
- Volume :
- 15
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of cancer research and therapeutics
- Accession number :
- edsair.doi.dedup.....d660837af1e8695541c4c7517bcb2faf