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Evaluation of the fetal kidney maturation by assessment of amniotic fluid alpha-1 microglobulin levels
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology. 90:55-61
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- Objective: To evaluate the fetal renal maturation by assessment of amniotic fluid microproteins and to show these proteins originate from fetal urine. Study design: Amniotic fluid proteins (total protein, albumin, high molecular weight protein-HMWP, low molecular weight protein-LMWP, α 1 -microglobulin and β 2 -microglobulin) were determined in 39 pregnant women at delivery and by amniocentesis in 30 pregnant women. These values were compared with first urine values of neonates with the same gestational age. Results: Albumin was the largest protein component in the amniotic fluid. LMWP showed an increase in the amniotic fluid until the end of the second trimester; and as pregnancy advanced a progressive decrease occurred in parallel to fetal renal maturation. After 26 weeks' gestation, a strong correlation was identified between LMWP levels and α 1 -microglobulin, and between LMWP and β 2 -microglobulin. No significant difference was detected between LMWP levels in the first urine of the neonates and in amniotic fluids. Conclusion: Microproteins in the fetal urine are of fetal origin. Fetal renal maturation can be evaluated by measuring microproteins in the amniotic fluid. Fetal renal maturation is best reflected by α 1 -microglobulin.
- Subjects :
- medicine.medical_specialty
Amniotic fluid
Gestational Age
Kidney
Fetal Kidney
Fetal Organ Maturity
Predictive Value of Tests
Pregnancy
Albumins
Internal medicine
Alpha-Globulins
Humans
Medicine
Fetus
medicine.diagnostic_test
business.industry
Beta-2 microglobulin
Infant, Newborn
Proteins
Obstetrics and Gynecology
Amniotic Fluid
Molecular Weight
Endocrinology
medicine.anatomical_structure
Reproductive Medicine
Amniocentesis
Regression Analysis
Female
beta 2-Microglobulin
business
Alpha-1-microglobulin
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....d646158c30416979204c8dea7788efd6