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Evidence that the neurotrophic actions of alpha-MSH may derive from its ability to mimick the actions of a peptide formed in degenerating nerve stumps
- Source :
- Journal of neurological sciences, 64, 333. Elsevier
- Publication Year :
- 1984
-
Abstract
- The ability of α-MSH to facilitate the recovery of sensorimotor nerve function following crush lesion is restricted to a critical period following such a lesion. This period coincided with the initiation of sprouting and the disappearance of the 150 kD neurofilament protein from the degenerating distal stump of the nerve. Degenerating nerve contains a factor that is active in a bioassay system for MSH. This factor could not be detected in control nerves. The hypothesis is forwarded that a neurotrophic factor known to be present in degenerating nerve stumps is an α-MSH-like peptide formed by the breakdown of the 150 kD neurofilament protein.
- Subjects :
- medicine.medical_specialty
animal structures
Neurofilament
Sensation
Peptide
Nerve Tissue Proteins
Biology
Peptide hormone
Lesion
Geneeskunde
Intermediate Filament Proteins
Neurotrophic factors
Neurofilament Proteins
Internal medicine
medicine
Animals
Melanocyte-Stimulating Hormones
Nerve Growth Factors
chemistry.chemical_classification
Motor Neurons
integumentary system
Biological activity
Rats, Inbred Strains
Sciatic Nerve
Nerve Regeneration
Rats
Endocrinology
Neurology
chemistry
Nerve Degeneration
biology.protein
Electrophoresis, Polyacrylamide Gel
Female
Neurology (clinical)
medicine.symptom
Peptides
Sprouting
Neurotrophin
Subjects
Details
- ISSN :
- 0022510X
- Volume :
- 64
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of the neurological sciences
- Accession number :
- edsair.doi.dedup.....d643f245ddb7a9d7eb95f6cd0bc8af82