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WRL 105 STRAIN (H3N2) LIVE ATTENUATED INFLUENZA VACCINE: ACCEPTABILITY, REACTIVITY, AND ANTIBODY RESPONSE IN NORMAL, BRONCHITIC, AND GERIATRIC VOLUNTEERS
- Source :
- The Lancet. 307:1309-1311
- Publication Year :
- 1976
- Publisher :
- Elsevier BV, 1976.
-
Abstract
- The acceptability, reactivity, and antibody responses of recombinant WRL 105 strain, live, attenuated influenza virus vaccine administered intranasally were studied in seventeen normal adults, and in seventeen bronchitic and twenty-one geriatric volunteers. The effect on peak flow and 1-second forced expiratory volume (F.E.V.1) on the 3rd, 5th, and 7th days after vaccination was measured in the bronchitic and normal groups. Seroconversion occurred in 80% to tht homologous virus, in 40.6% to A/Victoria/3/75, and in 26.5% to A/England/864/75 in subjects with pre-vaccination haemagglutination inhibition titres of less than 1/40. A fourfold or greater increase in homologous anti-neuraminidase antibody was found in 48% of twenty-seven infected subjects when measured by a new elution inhibition technique. The frequency and nature of symptoms were similar in both infected and non-infected groups. No significant changes in F.E.V.1 occurred, but on days 5 and 7 there was a decrease in peak flow measurements in both infected and non-infected groups when assessed as the percentage change of the pre-vaccination value.
- Subjects :
- Adult
Male
Hemagglutination Inhibition Tests
Hemagglutination
Orthomyxoviridae
Neuraminidase
Peak Expiratory Flow Rate
Antibodies, Viral
Vaccines, Attenuated
Virus
Forced Expiratory Volume
Influenza, Human
Humans
Live attenuated influenza vaccine
Medicine
Seroconversion
Bronchitis
Administration, Intranasal
Aged
Clinical Trials as Topic
biology
business.industry
Age Factors
General Medicine
Middle Aged
biology.organism_classification
Vaccination
Evaluation Studies as Topic
Influenza Vaccines
Antibody Formation
Immunology
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 01406736
- Volume :
- 307
- Database :
- OpenAIRE
- Journal :
- The Lancet
- Accession number :
- edsair.doi.dedup.....d63a9dffd88fdaf9779cebef4ace8577