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Guidance-Cue Control of Horizontal Cell Morphology, Lamination, and Synapse Formation in the Mammalian Outer Retina
- Source :
- The Journal of Neuroscience. 32:6859-6868
- Publication Year :
- 2012
- Publisher :
- Society for Neuroscience, 2012.
-
Abstract
- In the vertebrate retina, neuronal circuitry required for visual perception is organized within specific laminae. Photoreceptors convey external visual information to bipolar and horizontal cells at triad ribbon synapses established within the outer plexiform layer (OPL), initiating retinal visual processing. However, the molecular mechanisms that organize these three classes of neuronal processes within the OPL, thereby ensuring appropriate ribbon synapse formation, remain largely unknown. Here we show that mice with null mutations inSema6AorPlexinA4(PlexA4) exhibit a pronounced defect in OPL stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting. Furthermore, these mutant horizontal cells exhibit aberrant dendritic arborization and reduced dendritic self-avoidance within the OPL. Ultrastructural analysis shows that the horizontal cell contribution to rod ribbon synapse formation inPlexA4−/−retinas is disrupted. These findings define molecular components required for outer retina lamination and ribbon synapse formation.
- Subjects :
- Male
Retinal Bipolar Cells
genetic structures
Retinal Photoreceptor Cell Outer Segment
Neurogenesis
Outer plexiform layer
Nerve Tissue Proteins
Receptors, Cell Surface
Dendrite
Semaphorins
Retinal Horizontal Cells
Biology
Ribbon synapse
Cell morphology
Article
Mice
chemistry.chemical_compound
medicine
Animals
Axon
Retina
General Neuroscience
Retinal
Dendrites
Cell biology
medicine.anatomical_structure
nervous system
chemistry
Mutation
Synapses
Female
sense organs
Neuroscience
Photoreceptor Cells, Vertebrate
Signal Transduction
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....d6283e632b689b76f7ef9f2be94549d8
- Full Text :
- https://doi.org/10.1523/jneurosci.0267-12.2012