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Circulating insulin-like growth factor 1 levels are reduced in very young children with Prader-Willi syndrome independent of anthropometric parameters and nutritional status
- Source :
- Clinical endocrinologyREFERENCES. 96(3)
- Publication Year :
- 2021
-
Abstract
- OBJECTIVE Insulin growth factor-1 (IGF-1) is used to evaluate growth hormone (GH) sufficiency and is decreased in children with Prader-Willi syndrome (PWS). Although IGF-1 is negatively affected by body size and nutritional status, both of which are impaired in PWS children, these variables are typically not considered when assessing IGF-1 levels in these subjects. Here, we compared IGF-1 levels in PWS children to controls matched for age, sex, anthropometric parameters, and nutritional status. DESIGN/PATIENTS/MEASUREMENTS The retrospective analysis included genetically diagnosed PWS subjects (n = 65, median age; 14.0 months) and controls (n = 111, 14.3 months) matched for age, sex, anthropometric parameters (height-standard deviation score [SDS], weight-SDS, body mass index-SDS), and serum albumin levels, a marker for nutritional status. IGF-1 SDS was compared between PWS subjects and controls after adjustment for confounding variables. The GH provocation test was performed in 29 PWS subjects, and IGF-1 SDS was compared between GH-sufficient (n = 20) and GH-deficient (n = 9) subjects. Spearman's rank correlation coefficient was performed to investigate the association between age and IGF-1 SDS. None had received GH or levothyroxine treatment. RESULTS After adjustment for confounding variables, IGF-1 SDS was significantly lower in PWS subjects than controls (-1.56 vs. -1.01, p = .003), while it was not different between GH-sufficient and GH-deficient PWS subjects. Correlation analysis failed to show an association between age and IGF-1 SDS both in control and PWS groups. CONCLUSIONS IGF-1 SDS is lower in very young children with PWS independent of anthropometric parameters and nutritional status, suggesting the presence of hypothalamic dysfunction of GH secretion.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Provocation test
Levothyroxine
Physiology
Nutritional Status
Insulin-like growth factor
Endocrinology
Internal medicine
Medicine
Humans
Insulin-Like Growth Factor I
Child
Rank correlation
Retrospective Studies
business.industry
Human Growth Hormone
Insulin
Confounding
nutritional and metabolic diseases
Infant
Nutritional status
Growth hormone secretion
nervous system diseases
Child, Preschool
Growth Hormone
business
Prader-Willi Syndrome
medicine.drug
Subjects
Details
- ISSN :
- 13652265
- Volume :
- 96
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinologyREFERENCES
- Accession number :
- edsair.doi.dedup.....d624c8a2301f2d8a11df0a2ee6148bb5