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ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
- Source :
- Endocrine-related cancer. 23(12)
- Publication Year :
- 2016
-
Abstract
- Approximately 15-20% of breast cancers (BC) show either membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 gene amplification. Until the development of MErbB-2-targeted therapies, this BC subtype, called ErbB-2-positive, was associated with increased metastatic potential and poor prognosis. Although these therapies have significantly improved overall survival and cure rates, resistance to available drugs is still a major clinical issue. In its classical mechanism, MErbB-2 activates downstream signaling cascades, which transduce its effects in BC. The fact that ErbB-2 is also present in the nucleus of BC cells was discovered over twenty years ago. Also, compelling evidence revealed a non-canonical function of nuclear ErbB-2 as a transcriptional regulator. As a deeper understanding of nuclear ErbB-2 actions would be crucial to the disclosure of its role as a biomarker and a target of therapy in BC, we will here review its function in BC, in particular, its role in growth, metastatic spreading and response to currently available MErbB-2-positive BC therapies. Fil: Elizalde, Patricia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Chervo, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Schillaci, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
- Subjects :
- 0301 basic medicine
CA15-3
Oncology
Cancer Research
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Receptor, ErbB-2
Endocrinology, Diabetes and Metabolism
Ciencias de la Salud
Antineoplastic Agents
Breast Neoplasms
BREAST CANCER GROWTH
NUCLEAR ERBB-2
RESPONSE TO ANTI-ERBB-2 THERAPIES
Receptor tyrosine kinase
Metastasis
03 medical and health sciences
0302 clinical medicine
Endocrinology
Breast cancer
ErbB
Internal medicine
Transcriptional regulation
medicine
Animals
Humans
Neoplasm Metastasis
biology
business.industry
Cancer
medicine.disease
ERBB-2 TRANSCRIPTIONAL ACTIVITY
Otras Ciencias de la Salud
Gene Expression Regulation, Neoplastic
030104 developmental biology
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
METASTASIS
biology.protein
Biomarker (medicine)
Female
business
Signal Transduction
Subjects
Details
- ISSN :
- 14796821
- Volume :
- 23
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Endocrine-related cancer
- Accession number :
- edsair.doi.dedup.....d61d169b3df059651d00e81b2a479b62