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Chemiluminescence Studies of Lipoperoxidation Processes in Arterial Hypertension and Stress
- Source :
- Acta Biomedica Scientifica, Vol 4, Iss 1, Pp 133-137 (2019)
- Publication Year :
- 2019
- Publisher :
- FSPSI SCFHHRP, 2019.
-
Abstract
- Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.
- Subjects :
- 0301 basic medicine
arterial hypertension
Antioxidant
Science
medicine.medical_treatment
Pharmacology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
law.invention
Lipid peroxidation
isiah rats
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
law
Male rats
medicine
oxidative stress
Chronic stress
Chemiluminescence
General Immunology and Microbiology
Chemistry
Highly selective
chemiluminescence
030104 developmental biology
Free radical oxidation
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 25879596 and 25419420
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Acta Biomedica Scientifica (East Siberian Biomedical Journal)
- Accession number :
- edsair.doi.dedup.....d61688d996103d557e59e67944b56d35
- Full Text :
- https://doi.org/10.29413/abs.2019-4.1.20