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Chemiluminescence Studies of Lipoperoxidation Processes in Arterial Hypertension and Stress

Authors :
L. R. Kolesnikova
Anastasiya S. Brichagina
Mariya I. Dolgikh
L. V. Natyaganova
Source :
Acta Biomedica Scientifica, Vol 4, Iss 1, Pp 133-137 (2019)
Publication Year :
2019
Publisher :
FSPSI SCFHHRP, 2019.

Abstract

Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.

Details

ISSN :
25879596 and 25419420
Volume :
4
Database :
OpenAIRE
Journal :
Acta Biomedica Scientifica (East Siberian Biomedical Journal)
Accession number :
edsair.doi.dedup.....d61688d996103d557e59e67944b56d35
Full Text :
https://doi.org/10.29413/abs.2019-4.1.20