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Prognostic factors and patterns of loco-regional failure in patients with R0 resected gallbladder cancer
- Source :
- HPB : the official journal of the International Hepato Pancreato Biliary Association. 22(8)
- Publication Year :
- 2019
-
Abstract
- Background In this study, risk factors for loco-regional recurrence in curative R0 resected gallbladder adenocarcinoma were investigated. Methods Patients with gallbladder adenocarcinoma with curative R0 resections between 2000 and 2016 were retrospectively reviewed. Loco-regional failure-free survival (LRFFS) and overall survival (OS) were analyzed using the Kaplan–Meier method; prognostic factors were analyzed using the Cox proportional hazards model. Based on the identified risk factors, patients were grouped for further analysis. Results A total of 272 patients were included for analysis; overall, 5-year LRFFS and OS were 83% and 81%, respectively. On multivariate analysis, 3 risk factors for LRFFS were identified; lymphovascular invasion, T3, and N1, by which patients were grouped; group 1 for 0 factor, group 2 for 1 factor and group 3 for 2 to 3 factors. The 5-year LRFFS in groups 1, 2, and 3 were 94%, 73%, and 40%, and the 5-year OS in groups 1, 2, and 3 were 90%, 75%, and 47%, respectively. LRFFS and OS differed significantly among groups (p Conclusion In patients with R0 resected gallbladder cancer, the presence of >1 risk factor increased the risk of loco-regional recurrence. Additional therapeutic strategy for these patients needs further consideration.
- Subjects :
- medicine.medical_specialty
Multivariate analysis
Lymphovascular invasion
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Overall survival
Humans
In patient
Risk factor
Gallbladder cancer
Therapeutic strategy
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Hepatology
Proportional hazards model
business.industry
medicine.disease
Prognosis
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Gallbladder Neoplasms
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 14772574
- Volume :
- 22
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Accession number :
- edsair.doi.dedup.....d6164625feda1d64ca3c66ec03e99752