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Cord blood transplants: early recovery of neutrophils from co-transplanted sibling haploidentical progenitor cells and lack of engraftment of cultured cord blood cells, as ascertained by analysis of DNA polymorphisms
- Source :
- Bone Marrow Transplantation. 28:355-363
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- The number of infused cells is a very important factor in cord blood transplant (CBT) engraftment. Prior ex vivo expansion of aliquots of transplanted cord blood (CB) units is being investigated as a procedure to increase engraftment potential, but results are difficult to evaluate due to a lack of markers for assessing the contribution of expanded cells. We transplanted five patients, infusing the best available CB unit and cells from a second donor simultaneously. In two patients, these cells were obtained from another frozen CB unit by CD34+positive selection and culture expansion; the other three patients received uncultured highly purified haploidentical CD34+ cells. The first two patients had DNA from the culture expanded CB cells detected only for a few days around day +11 when the absolute neutrophil count (ANC) was >200/μl; thereafter and when the ANC was
- Subjects :
- Adult
Graft Rejection
Male
Neutrophils
CD34
Cell Separation
Nuclear Family
Blood cell
medicine
Humans
Progenitor cell
Cells, Cultured
Transplantation Chimera
Transplantation
Polymorphism, Genetic
business.industry
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
Fetal Blood
Haematopoiesis
medicine.anatomical_structure
Haplotypes
Leukopoiesis
Leukemia, Myeloid
Cord blood
Acute Disease
Immunology
Absolute neutrophil count
Female
Stem cell
business
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....d608c7656d57df95b5786f2f48e3a180