Back to Search
Start Over
Role of Thyroid Hormones and mir-208 in Myocardial Remodeling in 5/6 Nephrectomized Rats
- Source :
- Archives of Medical Research. 44(8):616-622
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Background and AimsThyroid hormones exert important effects on heart remodeling through mir-208. The process may have a role in myocardial changes in chronic kidney disease where thyroid abnormalities are common. In this study the effect of T4 supplementation on left ventricle (LV) remodeling in 5/6 nephrectomized rats (5/6Nx) was analyzed.Methods5/6Nx rats and 5/6Nx under T4 supplementation (5/6Nx + T4) were compared with control (C) and thyroidectomized (Tx) rats. After 8 weeks of follow-up, LV was analyzed for α-MHC, β-MHC, TGF-β, and mir-208 expression, hydroxyproline content, and myocardial fibrosis. Serum collagenase activity was also analyzed.ResultsHeart weight increased in 5/6Nx rats compared to C, which was prevented with T4 supplementation (C, 1.5 ± 0.04; 5/6Nx, 1.8 ± 0.09; 5/6Nx + T4, 1.6 ± 0.07 g, p
- Subjects :
- medicine.medical_specialty
Heart failure
Myocardial remodeling
Hydroxyproline
chemistry.chemical_compound
Internal medicine
Chronic kidney disease
medicine
Heart fibrosis
Ventricular remodeling
Medicine(all)
business.industry
Tissue level
General Medicine
medicine.disease
Thyroid hormone
medicine.anatomical_structure
Endocrinology
chemistry
Ventricle
Thyroid hormones
Myocardial fibrosis
mir-208
business
Kidney disease
Subjects
Details
- ISSN :
- 01884409
- Volume :
- 44
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Archives of Medical Research
- Accession number :
- edsair.doi.dedup.....d5fe531fa06e4e09c2b322290bd001a9
- Full Text :
- https://doi.org/10.1016/j.arcmed.2013.11.005