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Effects of drospirenone-ethinylestradiol and/or metformin on CD4(+)CD28(null) T lymphocytes frequency in women with hyperinsulinemia having polycystic ovary syndrome: a randomized clinical trial
- Publication Year :
- 2013
-
Abstract
- To evaluate the long-term effects of drospirenone (DRSP)/ethinylestradiol (EE) alone, metformin alone, and DRSP/EE-metformin on CD4(+)CD28(null) T lymphocytes frequency, a cardiovascular risk marker, in patients with hyperinsulinemic polycystic ovary syndrome (PCOS).Randomized clinical trial.Ninety three patients with hyperinsulinemic PCOS were age matched and body mass index matched and randomized to receive a 6 months daily treatment with DRSP (3 mg)/EE (0.03 mg), or metformin (1500 mg), or DRSP/EE combined with metformin.CD4(+)CD28(null) T-cell frequencies.The DRSP/EE and metformin groups did not show any significant change in the CD4(+)CD28(null) frequency compared to the baseline. Interestingly, a statistically significant decrease in CD4(+)CD28(null) frequency occurred after 6 months of DRSP/EE-metformin (median 3-1.5; P.01). Of note, this statistically significant association was confirmed after adjusting for baseline values in DRSP/EE-metformin group by analysis of covariance (P.05).In women with hyperinsulinemic PCOS, combined therapy with DRSP/EE and metformin may reduce cardiovascular risk.
- Subjects :
- CD4-Positive T-Lymphocytes
Time Factors
endocrine system diseases
Rome
Ethinyl Estradiol
law.invention
Randomized controlled trial
law
Risk Factors
Hyperinsulinemia
Obstetrics and Gynecology
Polycystic ovary
Metformin
Treatment Outcome
Cardiovascular Diseases
Reproductive Control Agents
ethinylestradiol
Androstenes
Female
medicine.drug
Adult
CD28
medicine.medical_specialty
Adolescent
Young Adult
CD28 Antigens
Internal medicine
Ethinylestradiol
Hyperinsulinism
medicine
Humans
Hypoglycemic Agents
In patient
Antigens
Analysis of Variance
Chi-Square Distribution
Antigens, CD28
business.industry
nutritional and metabolic diseases
Drospirenone
medicine.disease
CD4 Lymphocyte Count
Endocrinology
Settore MED/40 - GINECOLOGIA E OSTETRICIA
polycystic ovary syndrome
business
metformin
Body mass index
drospirenone
CD4+CD28null T-lymphocytes
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d5fdf534e884c613419b6890dcc1064c