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Hypothalamic mechanism of corticotropin-releasing factor’s anorexigenic effect in Japanese quail (Coturnix japonica)
- Source :
- General and Comparative Endocrinology. 276:22-29
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Central administration of corticotropin-releasing factor (CRF), a 41-amino acid peptide, is associated with anorexigenic effects across various species, with particularly potent reductions in food intake in rodents and chickens (Gallus gallus domesticus), a species for which the most is known. The purpose of the current study was to determine the hypothalamic mechanism of CRF-induced anorexigenic effects in 7 day-old Japanese quail (Coturnix japonica), a less-intensely-selected gallinaceous relative to the chicken that can provide more evolutionary perspective. After intracerebroventricular (ICV) injection of 2, 22, or 222 pmol of CRF, a dose-dependent decrease in food intake was observed that lasted for 3 and 24 h for the 22 and 222 pmol doses, respectively. The 2 pmol dose had no effect on food or water intake. The numbers of c-Fos immunoreactive cells were increased in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) at 1 h post-injection in quail injected with 22 pmol of CRF. The hypothalamic mRNA abundance of proopiomelanocortin, melanocortin receptor subtype 4, CRF, and CRF receptor sub-type 2 was increased at 1 h in quail treated with 22 pmol of CRF. Behavior analyses demonstrated that CRF injection reduced feeding pecks and jumps and increased the time spent standing. In conclusion, results demonstrate that the anorexigenic effects of CRF in Japanese quail are likely influenced by the interaction between CRF and melanocortin systems and that injection of CRF results in species-specific behavioral changes.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Food intake
Corticotropin-Releasing Hormone
Drinking
Hypothalamus
Drinking Behavior
030209 endocrinology & metabolism
Gallus gallus domesticus
Coturnix
Eating
03 medical and health sciences
0302 clinical medicine
Endocrinology
Proopiomelanocortin
Melanocortin receptor
biology.animal
Internal medicine
medicine
Animals
RNA, Messenger
Injections, Intraventricular
030304 developmental biology
0303 health sciences
Messenger RNA
Behavior, Animal
biology
Coturnix japonica
Body Weight
digestive, oral, and skin physiology
Feeding Behavior
biology.organism_classification
Quail
Anorexia
biology.protein
Female
Animal Science and Zoology
Melanocortin
Proto-Oncogene Proteins c-fos
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 00166480
- Volume :
- 276
- Database :
- OpenAIRE
- Journal :
- General and Comparative Endocrinology
- Accession number :
- edsair.doi.dedup.....d5fa5e61b13324636500325ccc50a7ac