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Why all MODY variants are dominantly inherited: a hypothesis
- Source :
- Trends in Genetics. 38:321-324
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Maturity-onset diabetes in the young (MODY) comprises monogenic phenotypes of young-onset, insulinopenic diabetes. All its forms are dominantly inherited. Why? Are the pancreatic β cells only harmed by heterozygous variants? We propose that recessive MODYs do exist but have escaped detection due to lack of family history suggestive of monogenic inheritance.
Details
- ISSN :
- 01689525
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Trends in Genetics
- Accession number :
- edsair.doi.dedup.....d5f87a3691f9ecd1495734e0330c3c95
- Full Text :
- https://doi.org/10.1016/j.tig.2021.10.001