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Why all MODY variants are dominantly inherited: a hypothesis

Authors :
Jean-Baptiste Rivière
Constantin Polychronakos
Meihang Li
Source :
Trends in Genetics. 38:321-324
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

Maturity-onset diabetes in the young (MODY) comprises monogenic phenotypes of young-onset, insulinopenic diabetes. All its forms are dominantly inherited. Why? Are the pancreatic β cells only harmed by heterozygous variants? We propose that recessive MODYs do exist but have escaped detection due to lack of family history suggestive of monogenic inheritance.

Details

ISSN :
01689525
Volume :
38
Database :
OpenAIRE
Journal :
Trends in Genetics
Accession number :
edsair.doi.dedup.....d5f87a3691f9ecd1495734e0330c3c95
Full Text :
https://doi.org/10.1016/j.tig.2021.10.001