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Switch between Life History Strategies Due to Changes in Glycolytic Enzyme Gene Dosage in Saccharomyces cerevisiae▿ †
- Source :
- Applied and Environmental Microbiology, Applied and Environmental Microbiology, American Society for Microbiology, 2011, 77 (2), pp.452-459. ⟨10.1128/AEM.00808-10⟩
- Publication Year :
- 2010
- Publisher :
- American Society for Microbiology (ASM), 2010.
-
Abstract
- Adaptation is the process whereby a population or species becomes better fitted to its habitat through modifications of various life history traits which can be positively or negatively correlated. The molecular factors underlying these covariations remain to be elucidated. Using Saccharomyces cerevisiae as a model system, we have investigated the effects on life history traits of varying the dosage of genes involved in the transformation of resources into energy. Changing gene dosage for each of three glycolytic enzyme genes (hexokinase 2, phosphoglucose isomerase, and fructose-1,6-bisphosphate aldolase) resulted in variation in enzyme activities, glucose consumption rate, and life history traits (growth rate, carrying capacity, and cell size). However, the range of effects depended on which enzyme was expressed differently. Most interestingly, these changes revealed a genetic trade-off between carrying capacity and cell size, supporting the discovery of two extreme life history strategies already described in yeast populations: the “ants,” which have lower glycolytic gene dosage, take up glucose slowly, and have a small cell size but reach a high carrying capacity, and the “grasshoppers,” which have higher glycolytic gene dosage, consume glucose more rapidly, and allocate it to a larger cell size but reach a lower carrying capacity. These results demonstrate antagonist pleiotropy for glycolytic genes and show that altered dosage of a single gene drives a switch between two life history strategies in yeast.
- Subjects :
- 0106 biological sciences
Glucose-6-phosphate isomerase
Saccharomyces cerevisiae Proteins
INDUCED MUTATIONS
Physiology
[SDV]Life Sciences [q-bio]
Population
Saccharomyces cerevisiae
Genes, Fungal
Gene Dosage
Biology
010603 evolutionary biology
01 natural sciences
Applied Microbiology and Biotechnology
Gene dosage
03 medical and health sciences
Pleiotropy
ENVIRONMENTAL VARIATION
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology
education
Gene
030304 developmental biology
2. Zero hunger
Genetics
Enzyme Gene
0303 health sciences
education.field_of_study
Ecology
Aldolase A
TRADE-OFFS
YEAST HEXOKINASE
GLUCOSE-METABOLISM
biology.organism_classification
EVOLUTION
Enzymes
Glucose
Biochemistry
DROSOPHILA-MELANOGASTER
[SDE]Environmental Sciences
ARABIDOPSIS-THALIANA
biology.protein
METABOLIC-CONTROL ANALYSIS
Energy Metabolism
Glycolysis
TRAITS
Metabolic Networks and Pathways
Food Science
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 00992240 and 10985336
- Database :
- OpenAIRE
- Journal :
- Applied and Environmental Microbiology, Applied and Environmental Microbiology, American Society for Microbiology, 2011, 77 (2), pp.452-459. ⟨10.1128/AEM.00808-10⟩
- Accession number :
- edsair.doi.dedup.....d5f7ae92be38a3017bb6f2cd153a9465