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Cobalt-Catalyzed Monoselective Ortho-C–H Functionalization of Carboxamides with Organoaluminum Reagent
- Source :
- Organic Letters. 18:5628-5631
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- A simple triphenylphosphine-ligated cobalt catalyst is reported for the direct ortho-C-H methylation and ethylation of aromatic, heteroaromatic, alkenyl, and even aliphatic carboxamides with inexpensive organoaluminum reagents in the presence of a cheap alkyl chloride as oxidant. This reaction shows monoselectivity in contrast with previously established C-H methylation methodologies.
- Subjects :
- inorganic chemicals
chemistry.chemical_classification
010405 organic chemistry
Organic Chemistry
chemistry.chemical_element
Methylation
010402 general chemistry
01 natural sciences
Biochemistry
Chloride
0104 chemical sciences
Catalysis
Cobalt catalyst
chemistry
Reagent
medicine
Organic chemistry
Surface modification
Physical and Theoretical Chemistry
Cobalt
Alkyl
medicine.drug
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....d5d943a0bb2ebbb0f111e638066ce139