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Roles of One-carbon Metabolism in Preimplantation Period
- Source :
- Journal of Reproduction and Development. 58:38-43
- Publication Year :
- 2012
- Publisher :
- Japanese Society of Animal Reproduction, 2012.
-
Abstract
- One-carbon metabolism (OCM) can be seen as integrated metabolic pathways centered on the metabolism of two nutritional substances, folate and methionine. Mammalian oocytes and preimplantation embryos express almost all enzymes that participate in OCM, suggesting that they can independently metabolize OCM nutrients. A deficiency or excess of OCM nutrients and their metabolites during in vitro culture affects preimplantation development of mammalian embryos. Recent in vivo studies have demonstrated that specific OCM dietary interventions during the periconceptional (mainly oocyte growth and preimplantation) period can cause epigenetic alterations in DNA of offspring and program the long-term consequences in their health in adulthood. The epigenetic processes are likely to be implicated in the effects of OCM nutrients; however, understanding their effects at the level of specific genes and their implications in assisted reproductive technology will require further investigations.
- Subjects :
- Male
Offspring
medicine.medical_treatment
Embryonic Development
Biology
Epigenesis, Genetic
Mice
chemistry.chemical_compound
Folic Acid
Methionine
medicine
Animals
Humans
Epigenetics
Gene
Assisted reproductive technology
Metabolism
Oocyte
Rats
Cell biology
Metabolic pathway
Blastocyst
medicine.anatomical_structure
chemistry
Biochemistry
Oocytes
Cattle
Female
Animal Science and Zoology
Subjects
Details
- ISSN :
- 13484400 and 09168818
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Journal of Reproduction and Development
- Accession number :
- edsair.doi.dedup.....d5d333fa82e0a7f9571973a2af27acb1