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Bacillus subtilis Hfq: A role in chemotaxis and motility
- Source :
- Journal of Biosciences. 41:347-358
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Hfq is a global post-transcriptional regulator that modulates the translation and stability of target mRNAs and thereby regulates pleiotropic functions, such as growth, stress, virulence and motility, in many Gram-negative bacteria. However, comparatively little is known about the regulation and function(s) of Hfq in Gram-positive bacteria. Recently, in Bacillus subtilis, a role for Hfq in stationary phase survival has been suggested, although the possibility of Hfq having an additional role(s) cannot be ruled out. In this study we show that an ortholog of Hfq in B. subtilis is regulated by the stress sigma factor, sigma(B), in addition to the stationary phase sigma factor, sigma(H). We further demonstrate that Hfq positively regulates the expression of flagellum and chemotaxis genes (fla/che) that control chemotaxis and motility, thus assigning a new function for Hfq in B. subtilis.
- Subjects :
- Factor Sigma-H
0301 basic medicine
Regulator
Motility
Sigma Factor
Bacillus subtilis
Host Factor 1 Protein
Flagellum
Hfq
General Biochemistry, Genetics and Molecular Biology
Microbiology
03 medical and health sciences
Cell Movement
Sigma factor
Family
RNA, Messenger
Rna Chaperone Hfq
Function
Regulation of gene expression
Binding Protein Hfq
Virulence
biology
Chemotaxis
Translation (biology)
Gene Expression Regulation, Bacterial
Degu
General Medicine
biology.organism_classification
Cell biology
Bacillus Subtilis
030104 developmental biology
Genes
General Agricultural and Biological Sciences
Escherichia-Coli
Tolerance
Sm-Like Protein
Regulation
Subjects
Details
- ISSN :
- 09737138 and 02505991
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Biosciences
- Accession number :
- edsair.doi.dedup.....d5ced2d42040142a8b9c973297239d56