Back to Search
Start Over
Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention
- Source :
- Advances in Nutrition
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- Traditionally, cancer has been viewed as a set of diseases that are driven by the accumulation of genetic mutations, but we now understand that disruptions in epigenetic regulatory mechanisms are prevalent in cancer as well. Unlike genetic mutations, however, epigenetic alterations are reversible, making them desirable therapeutic targets. The potential for diet, and bioactive dietary components, to target epigenetic pathways in cancer is now widely appreciated, but our understanding of how to utilize these compounds for effective chemopreventive strategies in humans is in its infancy. This review provides a brief overview of epigenetic regulation and the clinical applications of epigenetics in cancer. It then describes the capacity for dietary components to contribute to epigenetic regulation, with a focus on the efficacy of dietary epigenetic regulators as secondary cancer prevention strategies in humans. Lastly, it discusses the necessary precautions and challenges that will need to be overcome before the chemopreventive power of dietary-based intervention strategies can be fully harnessed.
- Subjects :
- 0301 basic medicine
Secondary cancer
RNA, Untranslated
Phytochemicals
Medicine (miscellaneous)
Review
Biology
Bioinformatics
Chemoprevention
bioactive component
Epigenesis, Genetic
03 medical and health sciences
0302 clinical medicine
Neoplasms
medicine
Animals
Humans
Epigenetics
Enzyme Inhibitors
noncoding RNAs
Regulation of gene expression
Nutrition and Dietetics
Cancer prevention
DNA methylation
histone modifications
Cancer
medicine.disease
Diet
Histone Code
030104 developmental biology
Gene Expression Regulation
030220 oncology & carcinogenesis
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 21565376 and 21618313
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Advances in Nutrition
- Accession number :
- edsair.doi.dedup.....d5ca528d4e4e79a1bdb7efd6b4f9207b