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Defective Antigen Presentation Leads to Upregulation of PD1 and IL-10 in HIV-TB Co-Infection

Defective Antigen Presentation Leads to Upregulation of PD1 and IL-10 in HIV-TB Co-Infection

Authors :
Sharada Ramaseri Sunder
Naveenchandra Suryadevara
Vijaya Lakshmi Valluri
Satya Sudheer Pydi
Venkata Sanjeev Kumar Neela
Source :
Journal of Interferon & Cytokine Research. 40:310-319
Publication Year :
2020
Publisher :
Mary Ann Liebert Inc, 2020.

Abstract

Human immunodeficiency virus-tuberculosis (HIV-TB) co-infection poses a challenge to the immunologists in developing new diagnostic and therapeutic tools. Mechanisms behind the breakdown of the immune defense of the co-infected individual are poorly known. Numerous studies in HIV alone have revealed the role of PD1, TAP, and IL-10, but not in co-infection. The interaction of the 2 distinct bugs, which is resulting in domination over the host immune system, is still a lacuna. Hence, we aimed to portray functions of IL-10, TAP, and PD1 molecules in HIV-TB co-infection. Co-culture cells challenged with γ-irradiated M.Tb under various conditions resulted in high interleukin (IL)-10 secretion and high percentage of PD1 expression on CD8 T cells, which might be due to defective antigen presentation of TAP on dendritic cells and macrophages. Herein our observations provide an insight into the escape mechanisms by M.Tb in HIV-infected individuals from the host immune responses leading to TB co-infection.

Details

ISSN :
15577465 and 10799907
Volume :
40
Database :
OpenAIRE
Journal :
Journal of Interferon & Cytokine Research
Accession number :
edsair.doi.dedup.....d5c0e85b12df932fbb4d348408870d23
Full Text :
https://doi.org/10.1089/jir.2019.0243