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Defective Antigen Presentation Leads to Upregulation of PD1 and IL-10 in HIV-TB Co-Infection
Defective Antigen Presentation Leads to Upregulation of PD1 and IL-10 in HIV-TB Co-Infection
- Source :
- Journal of Interferon & Cytokine Research. 40:310-319
- Publication Year :
- 2020
- Publisher :
- Mary Ann Liebert Inc, 2020.
-
Abstract
- Human immunodeficiency virus-tuberculosis (HIV-TB) co-infection poses a challenge to the immunologists in developing new diagnostic and therapeutic tools. Mechanisms behind the breakdown of the immune defense of the co-infected individual are poorly known. Numerous studies in HIV alone have revealed the role of PD1, TAP, and IL-10, but not in co-infection. The interaction of the 2 distinct bugs, which is resulting in domination over the host immune system, is still a lacuna. Hence, we aimed to portray functions of IL-10, TAP, and PD1 molecules in HIV-TB co-infection. Co-culture cells challenged with γ-irradiated M.Tb under various conditions resulted in high interleukin (IL)-10 secretion and high percentage of PD1 expression on CD8 T cells, which might be due to defective antigen presentation of TAP on dendritic cells and macrophages. Herein our observations provide an insight into the escape mechanisms by M.Tb in HIV-infected individuals from the host immune responses leading to TB co-infection.
- Subjects :
- Adult
Antigen Presentation
Programmed Cell Death 1 Receptor
Immunology
Antigen presentation
Interleukin
HIV Infections
Mycobacterium tuberculosis
Cell Biology
Biology
Coculture Techniques
Interleukin-10
Up-Regulation
Interleukin 10
Immune system
Downregulation and upregulation
Virology
Humans
Tuberculosis
Cytotoxic T cell
Secretion
Co infection
Subjects
Details
- ISSN :
- 15577465 and 10799907
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Interferon & Cytokine Research
- Accession number :
- edsair.doi.dedup.....d5c0e85b12df932fbb4d348408870d23
- Full Text :
- https://doi.org/10.1089/jir.2019.0243