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An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases
- Source :
- Journal of Gastroenterology and Hepatology. 37:246-255
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Our understanding of the microbiome and its implications for human health and disease continues to develop. Fecal microbiota transplantation (FMT) is now an established treatment for recurrent Clostridioides difficile infection. There is also increasing evidence for the efficacy of FMT in inducing remission for mild-moderate ulcerative colitis. However, for other indications, data for FMT are limited, with randomized controlled trials rare, typically small and often conflicting. Studies are continuing to explore the role of FMT for many other conditions, including Crohn's disease, functional gut disorders, metabolic syndrome, modulating responses to chemotherapy, eradication of multidrug resistant organisms, and the gut-brain axis. In light of safety, logistical, and regulatory challenges, there is a move to standardized products including narrow spectrum consortia. However, the mechanisms underpinning FMT remain incompletely understood, including the role of non-bacterial components, which may limit success of novel microbial approaches.
- Subjects :
- Crohn's disease
Hepatology
Gastrointestinal Diseases
business.industry
Gastroenterology
Disease
Fecal bacteriotherapy
Fecal Microbiota Transplantation
medicine.disease
Bioinformatics
Inflammatory bowel disease
Ulcerative colitis
Treatment Outcome
medicine
Humans
Microbiome
business
Clostridioides
Irritable bowel syndrome
Subjects
Details
- ISSN :
- 14401746 and 08159319
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi.dedup.....d5bfe5b29add849dfe48b1c8d5e46638