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Fetal hypoxemia causes abnormal myocardial development in a preterm ex utero fetal ovine model
- Source :
- JCI Insight. 3
- Publication Year :
- 2018
- Publisher :
- American Society for Clinical Investigation, 2018.
-
Abstract
- In utero hypoxia is a major cause of neonatal morbidity and mortality and predisposes to adult cardiovascular disease. No therapies exist to correct fetal hypoxia. In a new ex utero fetal support system, we tested the hypothesis that hypoxemic support of the fetus impairs myocardial development, whereas normoxic support allows normal myocardial development. Preterm fetal lambs were connected via umbilical vessels to a low-resistance oxygenator and placed in a sterile-fluid environment. Control normoxic fetuses received normal fetal oxygenation, and hypoxemic fetuses received subphysiologic oxygenation. Fetuses with normal in utero development served as normal controls. Hypoxemic fetuses exhibited decreased maximum cardiac output in both ventricles, diastolic function, myocyte and myocyte nuclear size, and increased myocardial capillary density versus control normoxic fetuses. There were no differences between control normoxic fetuses in the fetal support system and normal in utero controls. Chronic fetal hypoxemia resulted in significant abnormalities in myocyte architecture and myocardial capillary density as well as systolic and diastolic cardiac function, whereas control fetuses showed no differences. This ex utero fetal support system has potential to become a significant research tool and novel therapy to correct fetal hypoxia.
- Subjects :
- Cardiac function curve
Cardiac output
medicine.medical_specialty
Diastole
030204 cardiovascular system & hematology
03 medical and health sciences
Fetal Heart
Fetus
0302 clinical medicine
Pregnancy
Internal medicine
Animals
Humans
Myocyte
Medicine
Hypoxia
Maternal-Fetal Exchange
reproductive and urinary physiology
Sheep
030219 obstetrics & reproductive medicine
business.industry
Myocardium
Uterus
Infant, Newborn
General Medicine
Oxygenation
Hypoxia (medical)
Oxygen
Disease Models, Animal
Fertility
Cardiovascular Diseases
In utero
embryonic structures
Cardiology
Female
medicine.symptom
business
Research Article
Subjects
Details
- ISSN :
- 23793708
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- JCI Insight
- Accession number :
- edsair.doi.dedup.....d5bd87b18904731d4a1bfbc1f544370a