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Bone-Specific Metastasis Pattern of Advanced-Stage Lung Adenocarcinoma According to the Localization of the Primary Tumor
- Source :
- Pathology and Oncology Research
- Publication Year :
- 2021
-
Abstract
- Background: Patients with advanced-stage lung adenocarcinoma (LADC) often develop distant metastases in the skeletal system. Yet, the bone-specific metastasis pattern is still controversial. We, therefore, aimed to examine how the primary tumor location affects bone specificity and survival in LADC patients diagnosed with skeletal metastases.Methods: In total, 209 bone-metastatic Caucasian LADC patients from two thoracic centers were included in this study. Focusing on the specific location of primary tumors and bone metastatic sites, clinicopathological variables were included in a common database and analyzed retrospectively. Skeletal metastases were diagnosed according to the contemporary diagnostic guidelines and confirmed by bone scintigraphy. Besides region- and side-specific localization, primary tumors were also classified as central or peripheral tumors based on their bronchoscopic visibility.Results: The most common sites for metastasis were the spine (n = 103) and the ribs (n = 60), followed by the pelvis (n = 36) and the femur (n = 22). Importantly, femoral (p = 0.022) and rib (p = 0.012) metastases were more frequently associated with peripheral tumors, whereas centrally located LADCs were associated with humeral metastases (p = 0.018). Moreover, we deduced that left-sided tumors give rise to skull metastases more often than right-sided primary tumors (p = 0.018). Of note, however, the localization of the primary tumor did not significantly influence the type of affected bones. Multivariate Cox regression analysis adjusted for clinical parameters demonstrated that central localization of the primary tumor was an independent negative prognostic factor for overall survival (OS). Additionally, as expected, both chemotherapy and bisphosphonate therapy conferred a significant benefit for OS.Conclusion: The present study demonstrates unique bone-specific metastasis patterns concerning primary tumor location. Peripherally located LADCs are associated with rib and femoral metastases and improved survival outcomes. Our findings might contribute to the development of individualized follow‐up strategies in bone-metastatic LADC patients and warrant further clinical investigations on a larger sample size.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Medizin
tumor localization
Adenocarcinoma of Lung
Bone Neoplasms
Bone and Bones
Pathology and Forensic Medicine
Metastasis
Internal medicine
medicine
Humans
Lung cancer
Aged
Retrospective Studies
Original Research
bone metastasis
Aged, 80 and over
Rib cage
adenocarcinoma
medicine.diagnostic_test
business.industry
Proportional hazards model
Bone metastasis
Pathology and Oncology Archive
General Medicine
Middle Aged
medicine.disease
Prognosis
Primary tumor
lung cancer
Bone scintigraphy
Adenocarcinoma
Female
metastasis pattern
business
Subjects
Details
- ISSN :
- 15322807
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Pathology oncology research : POR
- Accession number :
- edsair.doi.dedup.....d5bd06581e4695662176717ca9abc156