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Susceptibility of Epithelial Cells to Pseudomonas aeruginosa Invasion and Cytotoxicity Is Upregulated by Hepatocyte Growth Factor
- Source :
- Infection and Immunity. 66:3443-3446
- Publication Year :
- 1998
- Publisher :
- American Society for Microbiology, 1998.
-
Abstract
- Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the basolateral cell surface in polarized epithelial cells.
- Subjects :
- Immunology
Cell
Biology
Microbiology
Cell Line
Dogs
Cell polarity
medicine
Animals
Cytotoxicity
Tight junction
Hepatocyte Growth Factor
Cadherin
Cell Polarity
Epithelial Cells
Cadherins
Epithelium
Cell biology
Infectious Diseases
medicine.anatomical_structure
Cell culture
Pseudomonas aeruginosa
Molecular and Cellular Pathogenesis
Parasitology
Hepatocyte growth factor
medicine.drug
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....d5b54238bdb5ebfa1956ec2805f3df8c