Back to Search
Start Over
Heterotrimeric G Proteins and the Single-Transmembrane Domain IGF-II/M6P Receptor: Functional Interaction and Relevance to Cell Signaling
- Source :
- Molecular Neurobiology. 35:329-345
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- The G protein-coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Classical GPCR signaling constitutes ligand binding to a seven-transmembrane domain receptor, receptor interaction with a heterotrimeric G protein, and the subsequent activation or inhibition of downstream intracellular effectors to mediate a cellular response. However, recent reports on direct, receptor-independent G protein activation, G protein-independent signaling by GPCRs, and signaling of nonheptahelical receptors via trimeric G proteins have highlighted the intrinsic complexities of G protein signaling mechanisms. The insulin-like growth factor-II/mannose-6 phosphate (IGF-II/M6P) receptor is a single-transmembrane glycoprotein whose principal function is the intracellular transport of lysosomal enzymes. In addition, the receptor also mediates some biological effects in response to IGF-II binding in both neuronal and nonneuronal systems. Multidisciplinary efforts to elucidate the intracellular signaling pathways that underlie these effects have generated data to suggest that the IGF-II/M6P receptor might mediate transmembrane signaling via a G protein-coupled mechanism. The purpose of this review is to outline the characteristics of traditional and nontraditional GPCRs, to relate the IGF-II/M6P receptor's structure with its role in G protein-coupled signaling and to summarize evidence gathered over the years regarding the putative signaling of the IGF-II/M6P receptor mediated by a G protein.
- Subjects :
- G protein-coupled receptor kinase
GTPase-activating protein
Molecular Sequence Data
Neuroscience (miscellaneous)
Cell Communication
Biology
Heterotrimeric GTP-Binding Proteins
Receptor, IGF Type 2
Cell biology
Cellular and Molecular Neuroscience
G beta-gamma complex
Neurology
Biochemistry
Heterotrimeric G protein
Enzyme-linked receptor
Animals
Humans
cAMP-dependent pathway
5-HT5A receptor
Amino Acid Sequence
Signal Transduction
G protein-coupled receptor
Subjects
Details
- ISSN :
- 15591182 and 08937648
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Molecular Neurobiology
- Accession number :
- edsair.doi.dedup.....d5af713fe0fa326c3c31fc0566e3812f