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Alloimmunization among transfusion-dependent thalassemia patients

Authors :
Mehrangiz Ravarian
Mohammad Khajeh Daluei
Mohammad Reza Keramati
Houshang Rafatpanah
Zahra Badiei
Hossein Ayatollahi
Mohammad Hadi Sadeghian
Source :
Asian Journal of Transfusion Science
Publication Year :
2010

Abstract

Background: Thalassemia is a common hemoglobin disorder in Iran and one of the major public health problems. Although blood transfusions are lifesavers for thalassemia patients, they may be associated with some complications especially erythrocyte alloimmunization. The purpose of this study was to investigate the prevalence of red blood cell alloantibodies and to determine types of these antibodies among multiple-transfused thalassemic patients. Materials and Methods: A total of 313 thalassemia patients in the northeast of Iran, who received regular blood transfusion, were included in this study. Screening of antibodies was performed on fresh serum of all patients and then antibodies were identified in patients' serum that had positive antibody screening test using a panel of recognized blood group antigens. Results: We identified 12 alloantibodies in 9 patients (2.87%) that all were against Rhesus (Rh) blood group antigens (D, C, E). Three patients developed 2 antibodies, and others had one antibody. The most common alloantibodies were Anti-D (88.88%) and followed by Anti-C and Anti-E. Higher frequency of alloimmunization was observed in female, Rh negative and splenectomized patients. Conclusion: This study showed that evaluation of the packed cells for Rh (C, E) from the start of transfusion can be helpful in decreasing the rate of alloantibody synthesis.

Details

ISSN :
19983565
Volume :
3
Issue :
2
Database :
OpenAIRE
Journal :
Asian journal of transfusion science
Accession number :
edsair.doi.dedup.....d5a7d6785f57d0c7b887b1980cfe8cf6