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Alloimmunization among transfusion-dependent thalassemia patients
- Source :
- Asian Journal of Transfusion Science
- Publication Year :
- 2010
-
Abstract
- Background: Thalassemia is a common hemoglobin disorder in Iran and one of the major public health problems. Although blood transfusions are lifesavers for thalassemia patients, they may be associated with some complications especially erythrocyte alloimmunization. The purpose of this study was to investigate the prevalence of red blood cell alloantibodies and to determine types of these antibodies among multiple-transfused thalassemic patients. Materials and Methods: A total of 313 thalassemia patients in the northeast of Iran, who received regular blood transfusion, were included in this study. Screening of antibodies was performed on fresh serum of all patients and then antibodies were identified in patients' serum that had positive antibody screening test using a panel of recognized blood group antigens. Results: We identified 12 alloantibodies in 9 patients (2.87%) that all were against Rhesus (Rh) blood group antigens (D, C, E). Three patients developed 2 antibodies, and others had one antibody. The most common alloantibodies were Anti-D (88.88%) and followed by Anti-C and Anti-E. Higher frequency of alloimmunization was observed in female, Rh negative and splenectomized patients. Conclusion: This study showed that evaluation of the packed cells for Rh (C, E) from the start of transfusion can be helpful in decreasing the rate of alloantibody synthesis.
- Subjects :
- Positive antibody
medicine.medical_specialty
thalassemia
Blood transfusion
biology
Alloantibody
business.industry
Thalassemia
medicine.medical_treatment
Hematology
medicine.disease
Red blood cell
medicine.anatomical_structure
Internal medicine
Immunology
medicine
biology.protein
Immunology and Allergy
Transfusion dependent thalassemia
Original Article
Hemoglobin
Antibody
business
Rh blood group system
transfusion
Subjects
Details
- ISSN :
- 19983565
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Asian journal of transfusion science
- Accession number :
- edsair.doi.dedup.....d5a7d6785f57d0c7b887b1980cfe8cf6