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Cutting Edge: Th2 Cell Trafficking into the Allergic Lung Is Dependent on Chemoattractant Receptor Signaling
- Source :
- The Journal of Immunology. 169:651-655
- Publication Year :
- 2002
- Publisher :
- The American Association of Immunologists, 2002.
-
Abstract
- Th2 cells are recruited to the lung where they mediate the asthma phenotype. Since the molecular mechanisms regulating Th2 cell trafficking remain unknown, we sought to determine whether trafficking of Th2 cells into the lung is mediated by Gαi-coupled chemoattractant receptors. We show here that in contrast to untreated Th2 cells, pertussis toxin-treated Th2 cells were unable to traffic into the lung, airways, or lymph nodes following Ag challenge and therefore were unable to induce allergic inflammation in vivo. Pertussis toxin-treated Th2 cells were functional cells, however, and when directly instilled into the airways of mice, bypassing their need to traffic to the lung, were able to induce airway eosinophilic inflammation. These studies conclusively demonstrate that trafficking of Th2 cells into the lung is an active process dependent on chemoattractant receptors.
- Subjects :
- Integrins
Adoptive cell transfer
Ovalbumin
Immunology
Cell
Epitopes, T-Lymphocyte
Mice, Transgenic
Biology
Lymphocyte Activation
Pertussis toxin
Lymphocyte Depletion
Epitope
Allergic inflammation
Mice
Th2 Cells
Cell Movement
Intubation, Intratracheal
Respiratory Hypersensitivity
medicine
Animals
Immunology and Allergy
Virulence Factors, Bordetella
Pulmonary Eosinophilia
Receptor
Cells, Cultured
Aerosols
Inflammation
Mice, Inbred BALB C
Lung
Nebulizers and Vaporizers
Chemotaxis
respiratory system
Adoptive Transfer
respiratory tract diseases
Chemotaxis, Leukocyte
Mucus
medicine.anatomical_structure
Pertussis Toxin
Cell Migration Inhibition
Cytokines
Receptors, Chemokine
Lymph Nodes
Bronchoalveolar Lavage Fluid
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 169
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....d5a5a1795cce434f90b4fa7f10570fb3