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Apoptotic cell death and lupus
- Source :
- Springer Seminars in Immunopathology. 28:145-152
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Programmed cell death and the disposal of cell corpses by phagocytic cells are highly regulated ongoing processes essential for the survival and well-being of higher organisms. Abnormalities in the susceptibility of certain cells to receptor-induced death are known to lead to certain human diseases (e.g., autoimmune lymphoproliferative syndrome) and may contribute to the pathogenesis of systemic lupus erythematosus. Impaired clearance of apoptotic cells is also likely to be an important factor in lupus pathogenesis, though the biological basis of such a defect remains elusive. Finally, the process of apoptosis has been shown to contribute to lupus disease effector mechanisms. A better understanding of the role of apoptosis in lupus very likely will lead to improved diagnosis and therapy.
- Subjects :
- Autoimmune disease
Phagocytes
Programmed cell death
Systemic lupus erythematosus
business.industry
Immunology
Cell
Apoptosis
General Medicine
Disease
medicine.disease
Lymphoproliferative Disorders
Pathogenesis
medicine.anatomical_structure
Autoimmune lymphoproliferative syndrome
medicine
Animals
Humans
Lupus Erythematosus, Systemic
skin and connective tissue diseases
business
Subjects
Details
- ISSN :
- 14322196 and 03444325
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Springer Seminars in Immunopathology
- Accession number :
- edsair.doi.dedup.....d59de48f3a2180f7741bfcfd582a7a1a