Back to Search
Start Over
Extraction of koumine from Gelsemium Elegans Benth. and its therapeutic effect on collagen-induced arthritis in mice
- Source :
- Food Science and Technology (2021), Food Science and Technology, Issue: ahead, Published: 24 MAY 2021, Food Science and Technology v.42 2022, Food Science and Technology (Campinas), Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA), instacron:SBCTA, Food Science and Technology, Volume: 42, Article number: e10421, Published: 24 MAY 2021
- Publication Year :
- 2022
- Publisher :
- FapUNIFESP (SciELO), 2022.
-
Abstract
- This study aimed to investigate the therapeutic effect of koumine on collagen-induced arthritis (CIA) in mice. Koumine was extracted from Gelsemium Elegans Benth. The CIA model was established in Balb/c mice. Forty successfully modeled mice were randomly divided into model group and 2, 4 and 8 mg/kg koumine groups, 10 mice in each group. Another 10 normal mice were selected as control group. The 2, 4 and 8 mg/kg koumine groups were treated with 2, 4 and 8 mg/kg koumine, respectively, for three successive weeks. At the end of treatment, compared with model group, in 4 and 8 mg/kg koumine groups the arthritis index was significantly decreased (P < 0.05), the peripheral blood interleukin-17 level and T helper 17 (Th17) cell percentage were significantly decreased (P < 0.05), the peripheral blood interleukin-10 level and regulatory T (Treg) cell percentage were significantly increased (P < 0.05), the spleen tissue RORγt protein expression level was significantly decreased (P < 0.05), and the spleen tissue Foxp3 protein expression level was significantly increased (P < 0.05). In conclusion, koumine has therapeutic effect on CIA in mice. The mechanism may be related to its regulating the RORγt/Foxp3 expressions, thus correcting the Th17/Treg immune imbalance.
- Subjects :
- 0106 biological sciences
mice
Th17, Treg
Cell
Arthritis
Pharmacology
collagen-induced arthritis
01 natural sciences
0404 agricultural biotechnology
RAR-related orphan receptor gamma
010608 biotechnology
medicine
T1-995
TX341-641
Technology (General)
koumine
Gelsemium elegans
Nutrition. Foods and food supply
Chemistry
Therapeutic effect
FOXP3
04 agricultural and veterinary sciences
medicine.disease
040401 food science
Peripheral blood
medicine.anatomical_structure
Food Science
Biotechnology
Collagen-induced arthritis
Subjects
Details
- ISSN :
- 1678457X and 01012061
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Food Science and Technology
- Accession number :
- edsair.doi.dedup.....d59b08c46000bbe057d5dcb72e57c4cd
- Full Text :
- https://doi.org/10.1590/fst.10421