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Multivariate machine learning models for prediction of pathologic response to neoadjuvant therapy in breast cancer using MRI features: a study using an independent validation set
- Source :
- Breast cancer research and treatment. 173(2)
- Publication Year :
- 2018
-
Abstract
- PURPOSE: To determine whether a multivariate machine learning-based model using computer-extracted features of pre-treatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can predict pathologic complete response (pCR) to neoadjuvant therapy (NAT) in breast cancer patients. METHODS: Institutional review board approval was obtained for this retrospective study of 288 breast cancer patients at our institution who received NAT and had a pre-treatment breast MRI. A comprehensive set of 529 radiomic features was extracted from each patient’s pretreatment MRI. The patients were divided into equal groups to form a training set and an independent test set. Two multivariate machine learning models (logistic regression and a support vector machine) based on imaging features were trained to predict pCR in (a) all patients with NAT, (b) patients with neoadjuvant chemotherapy (NACT), and (c) triple negative or human epidermal growth factor receptor 2-positive (TN/HER2+) patients who had NAT. The multivariate models were tested using the independent test set, and the area under the receiver operating characteristics (ROC) curve (AUC) was calculated. RESULTS: Out of the 288 patients, 64 achieved pCR. The AUC values for predicting pCR in TN/HER+ patients who received NAT were significant (.707, 95%CI: 0.582–0.833, p < 0.002). CONCLUSIONS: The multivariate models based on pre-treatment MRI features were able to predict pCR in TN/HER2+ patients.
- Subjects :
- 0301 basic medicine
Adult
Cancer Research
Multivariate statistics
Receptor, ErbB-2
medicine.medical_treatment
Triple Negative Breast Neoplasms
Logistic regression
Machine learning
computer.software_genre
Mastectomy, Segmental
Article
Machine Learning
03 medical and health sciences
0302 clinical medicine
Breast cancer
Antineoplastic Combined Chemotherapy Protocols
medicine
Image Processing, Computer-Assisted
Breast MRI
Humans
Breast
Neoadjuvant therapy
Aged
Neoplasm Staging
Retrospective Studies
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Magnetic resonance imaging
Retrospective cohort study
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Neoadjuvant Therapy
030104 developmental biology
Treatment Outcome
Oncology
ROC Curve
030220 oncology & carcinogenesis
Feasibility Studies
Female
Artificial intelligence
business
computer
Subjects
Details
- ISSN :
- 15737217
- Volume :
- 173
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Breast cancer research and treatment
- Accession number :
- edsair.doi.dedup.....d59307eb907dd8e94ae29bfc2ecd6075