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MUC1 Expression by Immunohistochemistry Is Associated with Adverse Pathologic Features in Prostate Cancer: A Multi-Institutional Study
- Source :
- PloS one, vol 11, iss 11, PLoS ONE, PLoS ONE, Vol 11, Iss 11, p e0165236 (2016)
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- Author(s): Eminaga, Okyaz; Wei, Wei; Hawley, Sarah J; Auman, Heidi; Newcomb, Lisa F; Simko, Jeff; Hurtado-Coll, Antonio; Troyer, Dean A; Carroll, Peter R; Gleave, Martin E; Lin, Daniel W; Nelson, Peter S; Thompson, Ian M; True, Lawrence D; McKenney, Jesse K; Feng, Ziding; Fazli, Ladan; Brooks, James D | Abstract: BackgroundThe uncertainties inherent in clinical measures of prostate cancer (CaP) aggressiveness endorse the investigation of clinically validated tissue biomarkers. MUC1 expression has been previously reported to independently predict aggressive localized prostate cancer. We used a large cohort to validate whether MUC1 protein levels measured by immunohistochemistry (IHC) predict aggressive cancer, recurrence and survival outcomes after radical prostatectomy independent of clinical and pathological parameters.Material and methodsMUC1 IHC was performed on a multi-institutional tissue microarray (TMA) resource including 1,326 men with a median follow-up of 5 years. Associations with clinical and pathological parameters were tested by the Chi-square test and the Wilcoxon rank sum test. Relationships with outcome were assessed with univariable and multivariable Cox proportional hazard models and the Log-rank test.ResultsThe presence of MUC1 expression was significantly associated with extracapsular extension and higher Gleason score, but not with seminal vesicle invasion, age, positive surgical margins or pre-operative serum PSA levels. In univariable analyses, positive MUC1 staining was significantly associated with a worse recurrence free survival (RFS) (HR: 1.24, CI 1.03-1.49, P = 0.02), although not with disease specific survival (DSS, Pg0.5). On multivariable analyses, the presence of positive surgical margins, extracapsular extension, seminal vesicle invasion, as well as higher pre-operative PSA and increasing Gleason score were independently associated with RFS, while MUC1 expression was not. Positive MUC1 expression was not independently associated with disease specific survival (DSS), but was weakly associated with overall survival (OS).ConclusionIn our large, rigorously designed validation cohort, MUC1 protein expression was associated with adverse pathological features, although it was not an independent predictor of outcome after radical prostatectomy.
- Subjects :
- 0301 basic medicine
Oncology
Male
Aging
medicine.medical_treatment
lcsh:Medicine
Pathology and Laboratory Medicine
Biochemistry
Negative Staining
Prostate cancer
0302 clinical medicine
Medicine and Health Sciences
80 and over
Medicine
Reproductive System Procedures
lcsh:Science
Cancer
Aged, 80 and over
Staining
Multidisciplinary
Tissue microarray
Clinical pathology
Prostatectomy
Prostate Cancer
Prostate Diseases
Seminal Vesicles
Middle Aged
Immunohistochemistry
Radical Prostatectomy
3. Good health
Treatment Outcome
030220 oncology & carcinogenesis
Patient Safety
Anatomy
Research Article
Urologic Diseases
PCA3
Adult
medicine.medical_specialty
Clinical Pathology
General Science & Technology
Urology
Surgical and Invasive Medical Procedures
and over
Research and Analysis Methods
Disease-Free Survival
03 medical and health sciences
Internal medicine
Humans
Pathological
Immunohistochemistry Techniques
Proportional Hazards Models
Aged
Surgical Excision
business.industry
Proportional hazards model
lcsh:R
Mucin-1
Reproductive System
Cancers and Neoplasms
Biology and Life Sciences
Prostatic Neoplasms
medicine.disease
Histochemistry and Cytochemistry Techniques
Genitourinary Tract Tumors
030104 developmental biology
Specimen Preparation and Treatment
Multivariate Analysis
Immunologic Techniques
lcsh:Q
business
Biomarkers
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- PloS one, vol 11, iss 11, PLoS ONE, PLoS ONE, Vol 11, Iss 11, p e0165236 (2016)
- Accession number :
- edsair.doi.dedup.....d5828c07efeb35acdd336ac8efe258eb