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More Advanced Hepatic Fibrosis in Hispanics with Chronic Hepatitis C Infection: Role of Patient Demographics, Hepatic Necroinflammation, and Steatosis
- Source :
- The American Journal of Gastroenterology. 101:1817-1823
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- We sought to assess whether Hispanics have more advanced hepatitis C virus (HCV)-related liver disease than non-Hispanic whites (NHW) and to identify contributory factors.Patients were recruited from the Los Angeles county hepatitis clinic. Liver fibrosis and necroinflammation (NI) were assessed by the Ishak scoring system. Hepatic steatosis was graded as 0-4.A total of 232 patients were evaluated, 63 NHW and 169 Hispanic. Hispanics were older and had a higher prevalence of blood transfusion (40%vs 21%), obesity (body mass index30) (47%vs 21%), diabetes mellitus (DM) (16%vs 5%), and hepatic steatosis (79%vs 47%), p0.02. Independent predictors of hepatic steatosis were Hispanic ethnicity (odds ratio [OR] 3.8, 95% CI 1.7-8.7, p= 0.001) and obesity (OR 5.7, 95% CI 2.3-14.1, p= 0.0002). Compared with NHW, Hispanics also had higher fibrosis stage (3.3 +/- 2 vs 2.3 +/- 6.9, p= 0.001), NI grade (6.4 +/- 1.8 vs 5.6 +/- 1.6, p= 0.002), and faster fibrosis progression/yr (0.14 +/- 0.09 vs 0.09 +/- 0.07, p= 0.0002). Presence of DM (OR 2.9, p= 0.02), grade 1-2 hepatic steatosis (OR 2.3, p= 0.03), AST/ALT1 (OR 4.3, p= 0.01), NI grade (OR 1.7, p0.0001), age at biopsy (OR 1.1, p0.0001), and serum bilirubin (OR 5.4, p0.0001) were independent predictors of fibrosis stageor =4.This study confirms that Hispanics have more advanced hepatic fibrosis than NHW. This is related to older age, higher NI grade, and greater prevalence of hepatic steatosis and DM.
- Subjects :
- Male
medicine.medical_specialty
Patient demographics
Gastroenterology
Necrosis
Risk Factors
Fibrosis
Internal medicine
Humans
Medicine
Survival analysis
Demography
Inflammation
Chi-Square Distribution
Hepatology
business.industry
Fatty liver
Hispanic or Latino
Hepatitis C
Hepatitis C, Chronic
Middle Aged
medicine.disease
Survival Analysis
Fatty Liver
Logistic Models
Female
Viral disease
Steatosis
business
Hepatic fibrosis
Subjects
Details
- ISSN :
- 15720241 and 00029270
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- The American Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....d57df19d3e0aeb56795531828a7fd995