Back to Search
Start Over
Response of man to infection with Vibrio cholerae. I. Clinical, serologic, and bacteriologic responses to a known inoculum
- Source :
- The Journal of infectious diseases. 129(1)
- Publication Year :
- 1974
-
Abstract
- The spectrum of illness and the immunologic response produced by cholera in volunteers were studied. The strains of Vibrio cholerae used were classical Inaba 569B and classical Ogawa 395. An oral dose of 108 organisms in buffered saline was required to induce the diarrhea of cholera. When given with live organisms, NaHCO3 lowered the infecting dose from 108 to 104 organisms. Clinical manifestations of infection varied from culturally positive formed stools to "rice water" diarrhea. Severe diarrhea did not have an explosive onset but rather progressively increased in volume during a 24-hr period. In 45% of cases the stool was positive for V. cholerae before the onset of diarrhea. Titers of vibriocidal antibody rose after diarrhea, peaked the second week after challenge, and rapidly fell during the next four weeks.
- Subjects :
- Diarrhea
Male
Administration, Oral
Biology
medicine.disease_cause
Microbiology
Serology
Feces
food
Cholera
medicine
Immunology and Allergy
Humans
Vibrio cholerae
Gastric Juice
Gastric Acidity Determination
Rice water
Hydrogen-Ion Concentration
medicine.disease
Virology
Antibodies, Bacterial
food.food
Titer
Bicarbonates
Infectious Diseases
biology.protein
Antitoxins
medicine.symptom
Antibody
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 129
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....d57b9aa65af3b213781ba0022a6b670f