Back to Search
Start Over
Selective ortho-bromination of substituted benzaldoximes using Pd-catalyzed C-H activation : Application to the synthesis of substituted 2-bromobenzaldehydes
- Source :
- Journal of Organic Chemistry, Journal of Organic Chemistry, American Chemical Society, 2011, 76 (15), pp.6414-6420
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- Substituted 2-bromobenzaldehydes were synthesized from benzaldehydes using a three-step sequence involving a selective palladium-catalyzed ortho-bromination as the key step. O-Methyloxime serves as a directing group in this reaction. A rapid deprotection of substituted 2-bromobenzaldoximes afforded substituted 2-bromobenzaldehydes with good overall yields.
- Subjects :
- Halogenation
Molecular Structure
Chemistry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Organic Chemistry
[CHIM.ORGA] Chemical Sciences/Organic chemistry
Combinatorial chemistry
Catalysis
[ CHIM.ORGA ] Chemical Sciences/Organic chemistry
Benzaldehydes
Molecule
Palladium
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- Language :
- English
- ISSN :
- 00223263 and 15206904
- Database :
- OpenAIRE
- Journal :
- Journal of Organic Chemistry, Journal of Organic Chemistry, American Chemical Society, 2011, 76 (15), pp.6414-6420
- Accession number :
- edsair.doi.dedup.....d57b869d959e7c9b5be5875d98ee0fb4