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Comparison of the efficacy of sitagliptin and glimepiride dose-up in Japanese patients with type 2 diabetes poorly controlled by sitagliptin and glimepiride in combination
- Source :
- Journal of Diabetes Investigation
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Aims/Introduction The goal of the study was to examine the effects of sitagliptin dose-up or glimepiride dose-up in Japanese patients with type 2 diabetes who were controlled inadequately by sitagliptin and glimepiride in combination. Materials and Methods A multicenter, prospective, randomized, open-label study was carried out in 50 patients with type 2 diabetes treated with sitagliptin and low-dose glimepiride. The patients were randomly assigned to receive the addition of 50 mg/day sitagliptin or 0.5 mg/day glimepiride. The primary end-point was the percentage change in glycated hemoglobin (HbA1c). Results During a follow-up period, the difference in the percentage changes in HbA1c between the two groups was not significant (P = 0.13). However, HbA1c was significantly decreased by glimepiride dose-up (P
- Subjects :
- medicine.medical_specialty
Combination therapy
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
Pharmacology
Gastroenterology
chemistry.chemical_compound
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Sitagliptin
In patient
business.industry
Glimepiride
Significant difference
Articles
General Medicine
medicine.disease
Clinical Trial
Clinical Science and Care
Arachidonic acid
chemistry
Glycated hemoglobin
business
medicine.drug
Subjects
Details
- ISSN :
- 20401116
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Investigation
- Accession number :
- edsair.doi.dedup.....d57a86f712a695293a59bc1e4d14c571
- Full Text :
- https://doi.org/10.1111/jdi.12151