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The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo
- Source :
- Science. 264:561-563
- Publication Year :
- 1994
- Publisher :
- American Association for the Advancement of Science (AAAS), 1994.
-
Abstract
- In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus. The IgA response in the lungs was completely restored after intranasal infection with recombinant vaccinia viruses engineered to express IL-6. These findings demonstrate a critical role for IL-6 in vivo in the development of local IgA antibody responses and illustrate the effectiveness of vector-directed cytokine gene therapy.
- Subjects :
- Immunoglobulin A
Ovalbumin
medicine.medical_treatment
Plasma Cells
Vaccinia virus
Transfection
Virus
Mice
chemistry.chemical_compound
Immune system
In vivo
Vaccinia
medicine
Animals
Mesentery
Intestinal Mucosa
Interleukin 6
Lung
Mucous Membrane
Multidisciplinary
biology
Interleukin-6
Cytokine
chemistry
Immunoglobulin G
Mutation
Immunology
biology.protein
Lymph Nodes
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....d57a7b0424f9bd1c36c62812a2254860