Back to Search
Start Over
Multiple-Antibiotic Resistance Mediated by Structurally Related IncL/M Plasmids Carrying an Extended-Spectrum β-Lactamase Gene and a Class 1 Integron
- Source :
- Antimicrobial Agents and Chemotherapy. 44:2911-2914
- Publication Year :
- 2000
- Publisher :
- American Society for Microbiology, 2000.
-
Abstract
- A conjugative IncL/M plasmid (pSEM) conferring resistance to gentamicin, amikacin, kanamycin, sulfonamides, and expanded-spectrum cephalosporins was found in pathogenic strains of Salmonella enterica serotype Typhimurium. Resistance to aminoglycosides was encoded by a sul1 -type class 1 integron (In-t3). An extended-spectrum beta-lactamase gene, bla SHV-5 , was identified 3.5 kb downstream of the integrase ( intI1 ) gene of In-t3. Nucleotide sequence analysis of the 5.3-kb bla SHV-5 –In-t3 region of pSEM highlighted striking similarities with IncL/M plasmids isolated from nosocomial gram-negative pathogens, conferring resistance to expanded-spectrum cephalosporins and aminoglycosides.
- Subjects :
- kanamycin
Integrins
antibiotic resistance
polymerase chain reaction
Drug Resistance
Integron
Plasmid
Antibiotics
Agar Gel
amikacin
antibiotic agent
Pharmacology (medical)
ceftazidime
Non-U.S. Gov't
Antibacterial agent
Cephalosporin Resistance
Electrophoresis, Agar Gel
Genetics
biology
Genetic transfer
article
aminoglycoside antibiotic agent
aztreonam
beta lactamase
cefamandole
cefotaxime
cefoxitin
ceftriaxone
cephalosporin derivative
gentamicin
imipenem
spectinomycin
streptomycin
sulfonamide
trimethoprim, antibiotic resistance
bacterial infection
Gram negative infection
hospital infection
multidrug resistance
nonhuman
nucleotide sequence
priority journal
Salmonella enterica, Antibiotics
Antibiotics, Aminoglycoside
beta-Lactamases
Chromosome Mapping
Drug Resistance, Multiple
Plasmids
Salmonella enterica
Support, Non-U.S. Gov't
Kanamycin
Anti-Bacterial Agents
Infectious Diseases
Support
Multiple
medicine.drug
Electrophoresis
Microbiology
Antibiotic resistance
Mechanisms of Resistance
medicine
trimethoprim
Pharmacology
Aminoglycoside
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
biology.organism_classification
Aminoglycosides
biology.protein
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....d56e482fe5e870ec738610a36f02f0d8