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Idazoxan and Efaroxan Potentiate the Endurance Performances and the Antioxidant Activity of Ephedrine in Rats
- Source :
- Medicina, Vol 57, Iss 194, p 194 (2021), Medicina, Medicina; Volume 57; Issue 3; Pages: 194, Volume 57, Issue 3
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background and objectives: The connections between the imidazoline system and multiple other neurotransmitter systems in the brain (adrenergic, dopaminergic, serotoninergic, glutamatergic, opioid) indicate the complexity of the mechanisms underlying motor activity and behavior. The aim of the present research was to investigate the effects of the combination of ephedrine (EPD) and imidazoline antagonists idazoxan (IDZ) and efaroxan (EFR) on the endurance performance in the treadmill test in rats. Materials and Methods: We used Wistar rats distributed as follows: Group 1 (Control) receiving distilled water 0.3 mL/100 g body weight<br />Group 2 (EPD) receiving 20 mg/kg ephedrine<br />Group 3 (EPD + IDZ) receiving 20 mg/kg ephedrine + 3 mg/kg idazoxan<br />Group 4 (EPD + EFR) receiving 20 mg/kg ephedrine + 1 mg/kg efaroxan. An additional group (C) of animals receiving 0.3 mL/100 g body weight distilled water (but not subjected) to effort was used. Endurance capacity was evaluated using a treadmill running PanLAB assay. The evaluation of the substances’ influence on oxidative stress was performed by spectrophotometric determination of superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity. Results: Treatment with EPD-IDZ and EPD-EFR were correlated with a longer distance traveled on the belt and with a decrease in the necessary electric shocks to motivate the animal to continue running in the forced locomotion test. Additionally, an increase in the activity of antioxidant enzymes was found. Conclusions: Idazoxan and efaroxan potentiated the physical effort-related effects of ephedrine with regard to endurance capacity and antioxidant activity in rats.
- Subjects :
- Medicine (General)
Antioxidant
medicine.medical_treatment
Imidazoline receptor
Adrenergic
imidazoline
Pharmacology
Antioxidants
Article
ephedrine
chemistry.chemical_compound
R5-920
medicine
idazoxan
efaroxan
exercise
oxidative stress
endurance
Animals
Ephedrine
Rats, Wistar
Adrenergic alpha-Antagonists
Benzofurans
chemistry.chemical_classification
Glutathione peroxidase
Imidazoles
General Medicine
Efaroxan
Rats
chemistry
Opioid
Idazoxan
medicine.drug
Subjects
Details
- Language :
- English
- Volume :
- 57
- Issue :
- 194
- Database :
- OpenAIRE
- Journal :
- Medicina
- Accession number :
- edsair.doi.dedup.....d56d8a57c310c7b65a1a8d482ecf04b9