Back to Search
Start Over
IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy
- Source :
- Allergology International, Vol 67, Iss 1, Pp 109-113 (2018)
- Publication Year :
- 2018
-
Abstract
- Background Interleukin-17 (IL-17A) is a mainly pro-inflammatory cytokine, and IL-17 signaling implicates in the development of allergic asthma. The polymorphism rs2275913 in the promoter region of the IL-17A gene has in previous studies been associated with asthma susceptibility. The objective was to evaluate the association between IL-17A rs2275913 (-197G>A) polymorphism and post-bronchiolitis asthma and/or allergic rhinitis in a prospective 11–13 years post-bronchiolitis follow-up. Methods 166 previously healthy full-term infants, hospitalized for bronchiolitis at age less than 6 months, were invited to follow-up visits at the ages of 5–7 years and 11–13 years. Asthma diagnoses and presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Blood samples for IL-17A rs2275913 (-197G>A) polymorphism were obtained during hospitalization or at the 5–7 years control visit. Results There were no significant differences between children with the wild GG and variant GA or AA genotype in the severity of bronchiolitis during hospitalization or in the outcomes until the age 5–7 years. At 11–13 years of age, children with the variant GA or AA genotype had significantly less often current asthma, use of ICSs during last 12 months or allergic rhinitis than those with the wild GG genotype. The ICS use during last 12 months retained the statistical significance in adjusted analyses (adjusted OR 0.25), whereas current asthma and allergic rhinitis marginally lost it. Conclusions The IL-17A rs2275913 (-197G>A) polymorphism decreased the risk of post-bronchiolitis asthma at 11–13 years of age, but not earlier in life, in the present prospective, long-term follow-up study.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
Male
medicine.medical_specialty
Adolescent
Biolääketieteet - Biomedicine
Inhaled corticosteroids
03 medical and health sciences
0302 clinical medicine
Risk Factors
Statistical significance
Internal medicine
Genotype
medicine
IL-17A
Immunology and Allergy
Humans
Child
Promoter Regions, Genetic
Asthma
Polymorphism, Genetic
business.industry
Interleukin-17
ta1183
Gene polymorphisms
Sisätaudit - Internal medicine
Age Factors
Infant, Newborn
RSV
Infant
Allergic asthma
General Medicine
Naisten- ja lastentaudit - Gynaecology and paediatrics
medicine.disease
Minor allele frequency
030104 developmental biology
030228 respiratory system
Bronchiolitis
Immunology
Female
Gene polymorphism
business
lcsh:RC581-607
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 13238930
- Volume :
- 67
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Allergology International
- Accession number :
- edsair.doi.dedup.....d552becdf896ece12f2959e782e8a6f0