Back to Search
Start Over
Improved Pregnancy Outcome in Patients With Rheumatoid Arthritis Who Followed an Ideal Clinical Pathway
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc, 2021.
-
Abstract
- Objective To assess the effect of optimal management of pregnancy on a composite outcome of miscarriage and complicated birth among women with rheumatoid arthritis (RA). Methods Data were extracted from health care databases of the Lombardy Region, Italy (2004-2013) as a part of the Record-Linkage on Rheumatic Diseases Study. Analyses included women with RA identified through a copayment exemption code (International Classification of Diseases, Ninth Revision, Clinical Modification code 714.0) and controls from the general population, ages 18-50 years. Seven health care quality indicators (HCQI) were constructed and summarized in 3 pathway indicators: diagnostic, therapeutic, and prenatal follow-up. Complicated birth or miscarriage were used to identify the adverse pregnancy outcome (APO). The relationship between HCQI and APO was analyzed using logistic models, and the results were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results Data from the study cohort included the first pregnancy observed in 443 patients with RA compared with 6,097 women belonging to the general population. In the RA population, patients who followed the 3 pathway indicators had a reduced risk of overall APO, with an OR of 0.60 (95% CI 0.39-0.94), and reduced risk of miscarriage/perinatal death, with an OR of 0.40 (95% CI 0.24-0.69), compared to those who did not follow the pathway indicators. Compared with the general population, patients with RA who met all HCQI during pregnancy displayed a risk of APO with an OR of 0.92 (95% CI 0.61-1.38) and miscarriage/perinatal death with an OR of 0.77 (95% CI 0.47-1.29). Conclusion The adherence to an ideal clinical pathway of pregnancy management in women with RA restored the risk of APO to that expected for the general population.
- Subjects :
- Adult
medicine.medical_specialty
Pregnancy, Rheumatoid Arthritis, Clinical Pathway
Adolescent
Databases, Factual
Population
Rheumatoid Arthritis
Risk Assessment
Pregnancy outcome
Miscarriage
Arthritis, Rheumatoid
Young Adult
03 medical and health sciences
0302 clinical medicine
Clinical pathway
Rheumatology
Risk Factors
Pregnancy
Internal medicine
Adverse Outcome Pathway
Quality Indicator
Humans
Medicine
education
Retrospective Studies
030203 arthritis & rheumatology
education.field_of_study
Adverse Outcome Pathways
business.industry
Ambientale
Retrospective cohort study
Odds ratio
Middle Aged
medicine.disease
Administrative Health Database
Abortion, Spontaneous
Pregnancy Complications
Cohort
Critical Pathways
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d54dd7604d074cf2ab267eaf87793713