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Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's Disease
Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's Disease
- Source :
- Journal of Alzheimer's disease, Journal of Alzheimers Disease, Journal of Alzheimer's Disease
- Publication Year :
- 2017
-
Abstract
- Background: Apolipoprotein E (ApoE) has been extensively studied in Alzheimers disease (AD), but little is known of apolipoprotein A-I (ApoA-I) in cerebrospinal fluid (CSF). Objective: Plasma lipids as well as ApoA-I and ApoE in plasma and CSF were determined and related to Mini-Mental State Examination (MMSE) score, APOE genotype, and CSF AD biomarkers. Methods: Consecutive patients with AD (n = 29), stable mild cognitive impairment (n = 13), other dementias (n = 14), and healthy controls (n = 18) were included at a single center. Results: AD patients had higher plasma triglycerides and lower CSF ApoA-I concentration than controls (both p
- Subjects :
- 0301 basic medicine
Apolipoprotein E
Male
Apolipoprotein B
Apolipoprotein A-I/cerebrospinal fluid
Apolipoprotein E4
Statistics as Topic
Disease
Apolipoprotein E4/cerebrospinal fluid
Single Center
Gastroenterology
0302 clinical medicine
Cerebrospinal fluid
Medicine(all)
Aged, 80 and over
biology
Alzheimer Disease/blood
General Neuroscience
General Medicine
Mental Status and Dementia Tests
Apolipoproteins/blood
Lipids
Psychiatry and Mental health
Clinical Psychology
Triglycerides/blood
Population study
lipids (amino acids, peptides, and proteins)
Female
medicine.medical_specialty
tau Proteins
03 medical and health sciences
Alzheimer Disease
Internal medicine
Plasma lipids
Cognitive Dysfunction/blood
mental disorders
medicine
Humans
In patient
Cognitive Dysfunction
Biology
Triglycerides
Aged
Apolipoprotein A-I
business.industry
Lipids/blood
tau Proteins/cerebrospinal fluid
030104 developmental biology
Apolipoproteins
biology.protein
Human medicine
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....d54b6d2d3b258aca33f9f6c6ed90c8b8