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Immune Reconstitution Inflammatory Syndrome and Cytomegalovirus Pneumonia Case Report: Highlights and Missing Links in Classification Criteria and Standardized Treatment

Authors :
María Guadalupe Zavala-Cerna
Arnulfo Hernán Nava-Zavala
Stefania Petarra-del Rio
Isidro G. Zavala-Trujillo
Georgina Aguilar-Portillo
Luis Anguiano-Landa
Adrian Rodriguez-Hernandez
Source :
Case Reports in Infectious Diseases, Vol 2017 (2017), Case Reports in Infectious Diseases
Publication Year :
2017
Publisher :
Hindawi Limited, 2017.

Abstract

Background. Cytomegalovirus (CMV) pulmonary involvement is rarely associated with IRIS; therefore, limited information is available. Case Presentation. Here, we describe the case of a 43-year-old HIV-infected male who developed an unusual case of IRIS after cytomegalovirus (CMV) pneumonia. Clinically there was a progressive and paradoxical worsening of respiratory distress, despite being treated for CMV after initiation with antiretroviral therapy. Chest X-ray revealed disseminated infiltrates in both lungs; chest CT-scan showed generalized lung involvement and mediastinal adenopathy. Pulmonary biopsy confirmed CMV pneumonia with the observation of typical viral inclusions on pneumocytes. Conclusions. CMV pneumonia can be associated with the development of IRIS requiring treatment with immunosuppressant’s and immunomodulatory drugs.

Details

Language :
English
ISSN :
20906633 and 20906625
Volume :
2017
Database :
OpenAIRE
Journal :
Case Reports in Infectious Diseases
Accession number :
edsair.doi.dedup.....d545f63f0f43fbfa69a87b4e6dc870ce