Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives

Authors :: Shintaro Nishimura
Kohji Kawabata
Takao Takaya
Hiroshi Sasaki
Kazuo Sakane
Nobuyoshi Yasuda
Source :: The Journal of Antibiotics. 43:1160-1168
Publication Year :: 1990
Publisher :: Japan Antibiotics Research Association, 1990.
Abstract: The synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. Both series possess potent antibacterial activity. Among them, 3-[(Z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.

Subjects :: Pharmacology
Cephem
Bacteria
Molecular Structure
Derivative (finance)
Stereochemistry
Biological property
Drug Discovery
Biological activity
Biology
Antibacterial activity
Cephalosporins

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