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Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
- Source :
- Journal of Tissue Engineering and Regenerative Medicine. 1:74-79
- Publication Year :
- 2007
- Publisher :
- Hindawi Limited, 2007.
-
Abstract
- To investigate the effectiveness of autologous culture-expanded bone marrow mesenchymal cell transplantation for repairing articular cartilage defects, we transplanted autologous culture-expanded bone marrow mesenchymal cells into nine full-thickness articular cartilage defects of the patello-femoral joints (including two kissing lesions) in the knees of three patients, a 31 year-old female, a 44 year-old male and a 45 year-old male. Three weeks before transplantation, bone marrow blood was aspirated from the iliac crest. Adherent cells were cultured with media containing autologous serum. Single-passaged cells were collected, embedded in a collagen solution (5 x 10(6) cells/ml), placed on a collagen sheet, gelated, transplanted into the defect and covered with autologous periosteum or synovium. Six months after transplantation, the patients' clinical symptoms had improved and the improvements have been maintained over the follow-up periods (17-27 months). Histology of the first patient 12 months after the transplantation revealed that the defect had been repaired with the fibrocartilaginous tissue. Magnetic resonance imaging of the second patient 1 year after transplantation revealed complete coverage of the defect, but we were unable to determine whether or not the material that covered the defects was hyaline cartilage. Autologous bone marrow mesenchymal cells transplantation may be an effective approach to promote the repair of articular cartilage defects.
- Subjects :
- Adult
Cartilage, Articular
Male
Pathology
medicine.medical_specialty
Biomedical Engineering
Medicine (miscellaneous)
Collagen sheet
Mesenchymal Stem Cell Transplantation
Transplantation, Autologous
Iliac crest
Biomaterials
medicine
Humans
Knee
Femur
Bone Marrow Transplantation
Stem cell transplantation for articular cartilage repair
Periosteum
Hyaline cartilage
business.industry
Cartilage
Patella
Middle Aged
Surgery
Transplantation
medicine.anatomical_structure
Female
Joints
Bone marrow
business
Subjects
Details
- ISSN :
- 19327005 and 19326254
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Tissue Engineering and Regenerative Medicine
- Accession number :
- edsair.doi.dedup.....d53d73f38b469afffcff2c6ca2256413