Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties

Authors :: Andrey S. Klymchenko
Alain Wagner
Aurélia Perino
Jean-Serge Remy
Emmanuelle Morin-Picardat
Yves Mély
D. Weltin
Patrick Neuberg
Zeinab Darwich
Nicolas Anton
Laboratoire de Biophotonique et Pharmacologie - UMR 7213 (LBP)
Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique
Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))
Conception et application de molécules bioactives (CAMB)
Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Source :: Chemical Communications, Chemical Communications, Royal Society of Chemistry, 2015, 51, pp.11595-11598
Publication Year :: 2015
Publisher :: Royal Society of Chemistry (RSC), 2015.
Abstract: A series of polydiacetylene (PDA) - based micelles were prepared from diacetylenic surfactant bearing polyethylene glycol, by increasing UV-irradiation times. These polymeric lipid micelles were analyzed by physicochemical methods, electron microscopy and NMR analysis. Cellular delivery of fluorescent dye suggests that adjusting the polymerization state is vital to reach the full in vitro potential of PDA-based delivery systems.

Full Text Access

Tools