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White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion
- Source :
- Brain research. 1592
- Publication Year :
- 2014
-
Abstract
- White matter abnormalities due to age-related cerebrovascular alterations is a common pathological hallmark associated with functional impairment in the elderly which has been modeled in chronically hypoperfused mice. 5-Methylcytosine (5mC) and its oxidized derivative 5-hydroxymethylcytosine (5hmC) are DNA modifications that have been recently linked with age-related neurodegeneration and cerebrovascular pathology. Here we conducted a pilot investigation of whether chronic cerebral hypoperfusion might affect genomic distribution of these modifications and/ or a Ten-Eleven Translocation protein 2 (TET2) which catalyses hydroxymethylation in white and grey matter regions of this animal model. Immunohistochemical evaluation of sham and chronically hypoperfused mice a month after surgery revealed significant (p
- Subjects :
- Male
Pathology
medicine.medical_specialty
Autophagy-Related Proteins
Pilot Projects
Biology
Grey matter
Corpus callosum
medicine.disease_cause
Corpus Callosum
Dioxygenases
White matter
Cytosine
Random Allocation
Neural Stem Cells
Proto-Oncogene Proteins
medicine
Animals
Progenitor cell
Gray Matter
Molecular Biology
Microglia
General Neuroscience
Neurodegeneration
Calcium-Binding Proteins
Microfilament Proteins
Intracellular Signaling Peptides and Proteins
medicine.disease
Immunohistochemistry
White Matter
DNA-Binding Proteins
Mice, Inbred C57BL
Cerebrovascular Disorders
Disease Models, Animal
Oxidative Stress
medicine.anatomical_structure
Chronic Disease
5-Methylcytosine
Neurology (clinical)
Neuroglia
Oxidative stress
Developmental Biology
Subjects
Details
- ISSN :
- 18726240
- Volume :
- 1592
- Database :
- OpenAIRE
- Journal :
- Brain research
- Accession number :
- edsair.doi.dedup.....d52d54e6c38f5f0c191505ce1337b980