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Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Authors :
Julie A. Fields
Danielle Brushaber
Jonathan Graff-Radford
Howie Rosen
Jeffrey L. Gunter
Leah K. Forsberg
Neill R. Graff-Radford
Dana Haley
Zbigniew K. Wszolek
David S. Knopman
Qin Chen
Rosa Rademakers
Adam L. Boxer
David T.W. Jones
Bradley F. Boeve
Timothy G. Lesnick
Ruth Kraft
Maria I. Lapid
Debra Gearhart
Kejal Kantarci
Nirubol Tosakulwong
Ralitza H. Gavrilova
Christina Dheel
Source :
Journal of neuroimaging : official journal of the American Society of Neuroimaging, vol 29, iss 5, Journal of Neuroimaging
Publication Year :
2019
Publisher :
eScholarship, University of California, 2019.

Abstract

Author(s): Chen, Qin; Boeve, Bradley F; Tosakulwong, Nirubol; Lesnick, Timothy; Brushaber, Danielle; Dheel, Christina; Fields, Julie; Forsberg, Leah; Gavrilova, Ralitza; Gearhart, Debra; Haley, Dana; Gunter, Jeffrey L; Graff-Radford, Jonathan; Jones, David; Knopman, David; Graff-Radford, Neill; Kraft, Ruth; Lapid, Maria; Rademakers, Rosa; Wszolek, Zbigniew K; Rosen, Howie; Boxer, Adam L; Kantarci, Kejal | Abstract: Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the neurochemical alterations accelerated during disease progression.MethodsWe identified eight MAPT mutations carriers who transitioned from asymptomatic to symptomatic disease during follow-up. All participants were longitudinally followed with an average of 7.75 years (range 4-11 years) and underwent two or more single voxel 1 H MRS examinations from the posterior cingulate voxel, with a total of 60 examinations. The rate of longitudinal change for each metabolite was estimated using linear mixed models. A flex point model was used to estimate the flex time point of the change in slope.ResultsThe decrease in the NAA/mI ratio accelerated 2.09 years prior to symptom onset, and continued to decline. A similar trajectory was observed in the presumed glial marker mI/Cr ratio accelerating 1.86 years prior to symptom onset.ConclusionsOur findings support the potential use of longitudinal 1 H MRS for monitoring the neurodegenerative progression in MAPT mutation carriers starting from the asymptomatic stage.

Details

Database :
OpenAIRE
Journal :
Journal of neuroimaging : official journal of the American Society of Neuroimaging, vol 29, iss 5, Journal of Neuroimaging
Accession number :
edsair.doi.dedup.....d5249c39c16956d42e818da64872f49f