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Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers
Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers
- Source :
- Journal of neuroimaging : official journal of the American Society of Neuroimaging, vol 29, iss 5, Journal of Neuroimaging
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Author(s): Chen, Qin; Boeve, Bradley F; Tosakulwong, Nirubol; Lesnick, Timothy; Brushaber, Danielle; Dheel, Christina; Fields, Julie; Forsberg, Leah; Gavrilova, Ralitza; Gearhart, Debra; Haley, Dana; Gunter, Jeffrey L; Graff-Radford, Jonathan; Jones, David; Knopman, David; Graff-Radford, Neill; Kraft, Ruth; Lapid, Maria; Rademakers, Rosa; Wszolek, Zbigniew K; Rosen, Howie; Boxer, Adam L; Kantarci, Kejal | Abstract: Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the neurochemical alterations accelerated during disease progression.MethodsWe identified eight MAPT mutations carriers who transitioned from asymptomatic to symptomatic disease during follow-up. All participants were longitudinally followed with an average of 7.75 years (range 4-11 years) and underwent two or more single voxel 1 H MRS examinations from the posterior cingulate voxel, with a total of 60 examinations. The rate of longitudinal change for each metabolite was estimated using linear mixed models. A flex point model was used to estimate the flex time point of the change in slope.ResultsThe decrease in the NAA/mI ratio accelerated 2.09 years prior to symptom onset, and continued to decline. A similar trajectory was observed in the presumed glial marker mI/Cr ratio accelerating 1.86 years prior to symptom onset.ConclusionsOur findings support the potential use of longitudinal 1 H MRS for monitoring the neurodegenerative progression in MAPT mutation carriers starting from the asymptomatic stage.
- Subjects :
- In vivo magnetic resonance spectroscopy
Adult
Male
Heterozygote
MRS
Magnetic Resonance Spectroscopy
longitudinal
Single voxel
Clinical Sciences
tau Proteins
Asymptomatic
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
MAPT
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Symptom onset
Longitudinal Studies
Original Research
Neurology & Neurosurgery
business.industry
Point model
Neurosciences
Brain
Frontotemporal lobar degeneration
Middle Aged
medicine.disease
converter
frontotemporal lobar degeneration
Clinical Investigative Study
Mutation (genetic algorithm)
Mutation
Disease Progression
Female
Neurology (clinical)
medicine.symptom
business
Nuclear medicine
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimaging : official journal of the American Society of Neuroimaging, vol 29, iss 5, Journal of Neuroimaging
- Accession number :
- edsair.doi.dedup.....d5249c39c16956d42e818da64872f49f