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International Intraductal Papillary Mucinous Neoplasms Registry
- Source :
- Pancreas. 46:306-310
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- OBJECTIVE: The aim of this study was to analyze the outcomes of a long-term intraductal papillary mucinous neoplasm (IPMN) registry and evaluate new guidelines. METHODS: A prospectively maintained IPMN registry involving 6 centers in Europe and the United States was used to collect the data. Patients with more than 1-year follow-up and no malignancy diagnosed within the first 3 months of surveillance were included. RESULTS: From 1999 to 2014, 620 patients were included. The median follow-up time was 3 years. Thirty-seven (6%) patients developed malignancy with a median time from IPMN diagnosis to malignancy of 10.3 months. The 1-, 5-, and 10-year actuarial rates of disease-free survival were 97%, 93%, and 92% respectively. Four hundred thirty-one patients met criteria for low-risk branch duct IPMN consisting of cyst size less than 3 cm, with no solid component or main duct dilation. Eight malignancies were diagnosed in this subgroup, all of them within the first 5 years. From this subcohort, 112 patients had a follow-up time of more than 5 years, and no malignancy was diagnosed. CONCLUSIONS: In IPMN lesions with low-risk features at baseline, the risk of progression to malignancy after the first 5 years of follow-up was minimal. Furthermore, the main cyst characteristics remained unchanged during their surveillance.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Malignancy
Main duct
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal Medicine
Carcinoma
medicine
Humans
Cyst
Longitudinal Studies
Registries
Aged
Gastrointestinal Neoplasms
Retrospective Studies
Hepatology
Intraductal papillary mucinous neoplasm
business.industry
Retrospective cohort study
Long term results
medicine.disease
Adenocarcinoma, Mucinous
Surgery
Pancreatic Neoplasms
Adenocarcinoma, Papillary
030220 oncology & carcinogenesis
Practice Guidelines as Topic
Disease Progression
Adenocarcinoma
Female
030211 gastroenterology & hepatology
Radiology
Pancreatic Cyst
business
Carcinoma, Pancreatic Ductal
Follow-Up Studies
Subjects
Details
- ISSN :
- 08853177
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....d51ebf5654345d48d7f25dc655367746